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Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review — Europe PMC PMID:31730635

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31730635
DOI: 10.1371/journal.pntd.0007792
License (as archived): CC0-1.0
Archived: 2026-11-10T02:20:28.854Z
SHA-256 of the archived text: bf862e6f38f32a2ad7278d285d1e2a068c8b325ea7749824f3ab1f242294a023
Stable URL of this page: https://metraipolis.com/documento/dc_ff26901066cb

How to cite

Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review — Europe PMC PMID:31730635 — Europe PMC (en), https://europepmc.org/article/MED/31730635 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ff26901066cb (Metraipolis archive dc_ff26901066cb, sha256 bf862e6f38f32a2ad7278d285d1e2a068c8b325ea7749824f3ab1f242294a023)

BibTeX

@misc{dcff26901066cb,
  title = {Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review — Europe PMC PMID:31730635},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31730635},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ff26901066cb; sha256 bf862e6f38f32a2ad7278d285d1e2a068c8b325ea7749824f3ab1f242294a023},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31730635. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic investigations, limiting interpretation of data in a global context. We conducted a scoping review to characterize current AFI research methodologies, identify global research gaps, and provide methodological research standardization recommendations. Methodology/findings: Using pre-defined terms, we searched Medline, Embase, and Global Health, for publications from January 1, 2005-December 31, 2017. Publications cited in previously published systematic reviews and an online study repository of non-malarial febrile illness etiologies were also included. We screened abstracts for publications reporting on human infectious disease, aimed at determining AFI etiology using laboratory diagnostics. One-hundred ninety publications underwent full-text review, using a standardized tool to collect data on study characteristics, methodology, and laboratory diagnostics. AFI case definitions between publications varied: use of self-reported fever as part of case definitions (28%, 53/190), fever cut-off value (38·0°C most commonly used: 45%, 85/190), and fever measurement site (axillary most commonly used: 19%, 36/190). Eighty-nine publications (47%) did not include exclusion criteria, and inclusion criteria in 13% (24/190) of publications did not include age group. No publications included study settings in Southern Africa, Micronesia & Polynesia, or Central Asia. We summarized standardized reporting practices, specific to AFI etiologic investigations that would increase inter-study comparability. Conclusions: Wider implementation of standardized AFI reporting methods, with multi-pathogen disease detection, could improve comparability of study findings, knowledge of the range of AFI etiologies, and their contributions to the global AFI burden. These steps can guide resource allocation, strengthen outbreak detection and response, target prevention efforts, and improve clinical care, especially in resource-limited settings where disease control often relies on empiric treatment. PROSPERO: CRD42016035666.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS neglected tropical diseases, 2019 (prima pubblicazione 2019-11-15).
Identificativi: PMID 31730635 · PMCID PMC6881070 · DOI 10.1371/journal.pntd.0007792.
Descrittori MeSH principali: Knowledge.
Pagina: https://europepmc.org/article/MED/31730635 — https://doi.org/10.1371/journal.pntd.0007792. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T02:17:33.599Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.