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11-Chloroasimilobine — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/11-Chloroasimilobine
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T15:53:52.119Z
SHA-256 of the archived text: c7f3444611ed05078faa02a47ec498170c65173350794f1af16ab5cc281474dc
Stable URL of this page: https://metraipolis.com/documento/dc_fdf6f2daffc2

How to cite

11-Chloroasimilobine — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/11-Chloroasimilobine (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_fdf6f2daffc2 (Metraipolis archive dc_fdf6f2daffc2, sha256 c7f3444611ed05078faa02a47ec498170c65173350794f1af16ab5cc281474dc)

BibTeX

@misc{dcfdf6f2daffc2,
  title = {11-Chloroasimilobine — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/11-Chloroasimilobine},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_fdf6f2daffc2; sha256 c7f3444611ed05078faa02a47ec498170c65173350794f1af16ab5cc281474dc},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/11-Chloroasimilobine. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

11-Chloroasimilobine, also known as 1-methoxy-2-hydroxy-11-chloronoraporphine, is a serotonin 5-HT2C receptor agonist of the noraporphine family. It is a synthetic compound and is the racemic 11-chloro derivative of the aporphine alkaloid asimilobine. The drug acts as a highly selective Gq-preferring biased agonist of the serotonin 5-HT2C receptor. Its EC50Tooltip half-maximal effective concentration (EmaxTooltip maximal efficacy) values were 36 nM (102%) for Gq signaling and 437 nM (62%) for β-arrestin2 recruitment. 11-Chloroasimilobine was inactive as an agonist of the serotonin 5-HT2A and 5-HT2B receptors at concentrations of up to 30,000 nM. It was also selective for the serotonin 5-HT2C receptor over a panel of other targets. The drug has been found to reverse the hyperlocomotion induced by dizocilpine (MK801) and phencyclidine (PCP) in rodents. The pharmacokinetics of 11-chloroasimilobine have been studied. The chemical synthesis of the compound has been described. 11-Chloroasimilobine was described in the scientific literature by Wangzhi Qin and colleagues in 2025. It had previously been patented in 2022.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «11-Chloroasimilobine» — https://en.wikipedia.org/wiki/11-Chloroasimilobine
Wikidata Q139414248 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q139414248
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/11-Chloroasimilobine?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1349136317, consultata il 2026-10-07T15:27:15.787Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 1d25164d6814075651cd1d7a175d7c98b62bf2714600298c815191ad741e50a9