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Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States — Europe PMC PMID:34280230

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34280230
DOI: 10.1371/journal.pone.0254998
License (as archived): CC0-1.0
Archived: 2026-11-03T15:53:46.986Z
SHA-256 of the archived text: 68019c52028b76cc7427203961a6aa3cc98068fcadaf8ccf360e1f886499b9f3
Stable URL of this page: https://metraipolis.com/documento/dc_fdaf7beeaf82

How to cite

Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States — Europe PMC PMID:34280230 — Europe PMC (en), https://europepmc.org/article/MED/34280230 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fdaf7beeaf82 (Metraipolis archive dc_fdaf7beeaf82, sha256 68019c52028b76cc7427203961a6aa3cc98068fcadaf8ccf360e1f886499b9f3)

BibTeX

@misc{dcfdaf7beeaf82,
  title = {Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States — Europe PMC PMID:34280230},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34280230},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fdaf7beeaf82; sha256 68019c52028b76cc7427203961a6aa3cc98068fcadaf8ccf360e1f886499b9f3},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34280230. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Scrapie is a slowly progressive neurodegenerative disease of small ruminants caused by an accumulation of an abnormal isoform of prion protein in the central nervous system. Polymorphisms of the prion protein gene (PRNP) strongly modulate scrapie resistance and incubation period in goats. The aim of this study was to identify PRNP genetic variability in goats across the United States. Blood from a total of 6,029 apparent scrapie disease-free goats from 654 operations and 19 breeds were analyzed. Sequencing of PRNP revealed 26 genotypes with different rates based on eight codons. The GG127, RR154, and QQ222 genotypes were predominant and showed a remarkably high rate across all goats. The QK222 and NS146 genotypes, known to be protective against scrapie, were found in 0.6% [with 95% CI = (0.3, 1.2)] and 22.0% [95% CI = (19.1, 25.2)] of goats, respectively. The QK222 genotype was found in 23.1% of Oberhasli goats tested, with 95%CI = (3.9, 68.7)] and 22.0% of Toggenburg goats tested with 95%CI = (9.7, 42.5)], while NS146 was found in 65.5% of Savannah goats tested, with 95%CI = (30.8, 89.9), 36.7% of Boer goats tested, with 95%CI = (33.1, 40.4), 36.3% of Nubian goats tested, with 95%CI = (27.0, 46.7)], and 35.6% of LaMancha goats tested, with 95%CI = (22.8, 50.8%). The MM142 and IM142 genotypes were found more frequently in goats on dairy operations, while the HR143, NS146, and ND146 genotypes were found more frequently in goats on meat operations. Goats in the east region had a higher percentage of goats with RH154, RQ211, and QK222 genotypes than goats in the west region. The results of this study showed high genetic variability of PRNP among the U.S. goat population, with differences by location and breed, and may serve as a rationale for development of goat breeding programs at the national level to mitigate the risk of scrapie.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-07-19).
Identificativi: PMID 34280230 · PMCID PMC8289333 · DOI 10.1371/journal.pone.0254998.
Pagina: https://europepmc.org/article/MED/34280230 — https://doi.org/10.1371/journal.pone.0254998. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-03T15:46:27.656Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.