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Evidence Before Accuracy: A MRI-PET Fusion Network for Alzheimer Disease Classification with Causal Regional Validation — arXiv:2609.34520

Source: arXiv (en)
Original: https://arxiv.org/abs/2609.34520
License (as archived): CC0-1.0
Archived: 2026-10-07T23:52:13.158Z
SHA-256 of the archived text: 0a716fde611d84579d37200367bf65c1b8f4a7abc437cdc64661d5ab854e7baf
Stable URL of this page: https://metraipolis.com/documento/dc_fd6acbc80bb3

How to cite

Evidence Before Accuracy: A MRI-PET Fusion Network for Alzheimer Disease Classification with Causal Regional Validation — arXiv:2609.34520 — arXiv (en), https://arxiv.org/abs/2609.34520 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fd6acbc80bb3 (Metraipolis archive dc_fd6acbc80bb3, sha256 0a716fde611d84579d37200367bf65c1b8f4a7abc437cdc64661d5ab854e7baf)

BibTeX

@misc{dcfd6acbc80bb3,
  title = {Evidence Before Accuracy: A MRI-PET Fusion Network for Alzheimer Disease Classification with Causal Regional Validation — arXiv:2609.34520},
  howpublished = {arXiv (en)},
  url = {https://arxiv.org/abs/2609.34520},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fd6acbc80bb3; sha256 0a716fde611d84579d37200367bf65c1b8f4a7abc437cdc64661d5ab854e7baf},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: arXiv (en), https://arxiv.org/abs/2609.34520. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Deep learning models for Alzheimer disease (AD) classification routinely report near-perfect discrimination, yet few are shown to rest on AD-relevant neurobiology rather than on dataset artifacts, subject-level leakage, or non-brain image content. We present a fusion network combining T1 MRI and FDG PET across axial, coronal, and sagittal planes, trained on ADNI consists of 554 paired subjects. The fusion model reaches AUC 0.962, accuracy 0.909, and F1 0.891, competitive with recent 3D CNN and multimodal transformer systems at substantially lower cost. We first quantify how much modality, plane and slice geometry matter. A validation-only search over slice centres and neighbour spacings moves AUC by 0.180 for MRI and 0.078 for PET, selecting narrow spacing for MRI and wide spacing for PET, with the chosen coronal centres falling on the hippocampal body and on the posterior cingulate respectively. The contribution, however, is the evidence layer built around that number. Shortcut controls collapse the model to AUC 0.622 (silhouette), 0.608 (exterior), and 0.500 (blank), and a label-permutation null yields 0.456. Forward region-of-interest (ROI) ablation shows that masking medial temporal cortex in MRI and the posterior default-mode network (DMN) in PET produces the largest shift in the AD logit, while area-matched controls remain indistinguishable from that null. Reverse ROI ablation shows that the medial temporal lobe alone retains 89.2% of above-chance discrimination in MRI and the posterior DMN alone retains 79.0% in PET. A quantitative comparison of attribution methods shows occlusion sensitivity reaching 3.5-5.0* enrichment inside a priori AD regions against 0.10-0.43* in controls. Ablation and attribution independently establish a biologically correct double dissociation: hippocampal evidence is carried by MRI, posterior cingulate evidence by PET.

Tema degli esploratori: statistica e scienza dei dati (retro-catalogo arXiv: annunci del 2026-09-29 in cs.CV).
Categorie arXiv: Computer Vision and Pattern Recognition (cs.CV).
Pagina del lavoro: https://arxiv.org/abs/2609.34520 — autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza: titolo e abstract sono metadati arXiv distribuiti in CC0 1.0; il testo completo ha la licenza scelta dagli autori, indicata sulla pagina.
Letto il 2026-10-07T23:29:27.385Z dalla pagina https://arxiv.org/catchup/cs.CV/2026-09-29?abs=True (consentita dal robots.txt di arxiv.org, con il suo crawl-delay).