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Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages — Europe PMC PMID:31725732

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31725732
DOI: 10.1371/journal.pone.0223955
License (as archived): CC0-1.0
Archived: 2026-11-10T02:17:08.482Z
SHA-256 of the archived text: da1d51adaf8c3bff931bbc415bbe1409e9dfd17b164cb5aefbd393e41d99a960
Stable URL of this page: https://metraipolis.com/documento/dc_fd41349a4ff4

How to cite

Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages — Europe PMC PMID:31725732 — Europe PMC (en), https://europepmc.org/article/MED/31725732 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fd41349a4ff4 (Metraipolis archive dc_fd41349a4ff4, sha256 da1d51adaf8c3bff931bbc415bbe1409e9dfd17b164cb5aefbd393e41d99a960)

BibTeX

@misc{dcfd41349a4ff4,
  title = {Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages — Europe PMC PMID:31725732},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31725732},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fd41349a4ff4; sha256 da1d51adaf8c3bff931bbc415bbe1409e9dfd17b164cb5aefbd393e41d99a960},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31725732. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

African swine fever (ASF) is a swine disease caused by a large, structurally complex, double-stranded DNA virus, African swine fever virus (ASFV). In domestic pigs, acute infection by highly virulent ASF viruses causes hemorrhagic fever and death. Previous work has suggested that ASFV pathogenesis is primarily mediated by host cytokines produced by infected monocytes and macrophages. To better understand molecular mechanisms mediating virus pathogenesis and immune evasion, we used transcriptome analysis to identify gene expression changes after ASFV infection in ex vivo swine macrophages. Our results suggest that the cytokines of TNF family including FASLG, LTA, LTB, TNF, TNFSF4, TNFSF10, TNFSF13B and TNFSF18 are the major causative cytokine factors in ASF pathogenesis via inducing apoptosis. Other up-regulated proinflammatory cytokines (IL17F and interferons) and down-regulated anti-inflammatory cytokine (IL10) may also significantly contribute to ASF pathogenesis and cause excessive tissue inflammatory responses. The differential expression of genes also indicates that ASFV could evade both the innate and adaptive immune responses by (i) inhibiting MHC Class II antigen processing and presentation, (ii) avoiding CD8+ T effector cells and neutrophil extracellular traps via decreasing expression of neutrophil/CD8+ T effector cell-recruiting chemokines, (iii) suppressing M1 activation of macrophages, (iv) inducing immune suppressive cytokines, and (v) inhibiting the processes of macrophage autophagy and apoptosis. These results provide novel information to further investigate and better understand the mechanism of pathogenesis and immune evasion of this devastating swine disease.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-11-14).
Identificativi: PMID 31725732 · PMCID PMC6855437 · DOI 10.1371/journal.pone.0223955.
Descrittori MeSH principali: Immune Evasion.
Pagina: https://europepmc.org/article/MED/31725732 — https://doi.org/10.1371/journal.pone.0223955. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T02:11:41.957Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.