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Per- and Polyfluoroalkyl Substances in Eutopic Endometrium Tissue and Risk of Endometriosis: Findings from the Investigating Mixtures of Pollutants and… — Europe PMC PMID:40257857

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40257857
DOI: 10.1289/ehp15852
License (as archived): CC0-1.0
Archived: 2026-10-06T09:52:25.682Z
SHA-256 of the archived text: 351b11b654f648a1692b3389e6cdaed55b8e9d20f5d7f1a8c167ac2c0a22c00c
Stable URL of this page: https://metraipolis.com/documento/dc_fd092c107ace

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Per- and Polyfluoroalkyl Substances in Eutopic Endometrium Tissue and Risk of Endometriosis: Findings from the Investigating Mixtures of Pollutants and… — Europe PMC PMID:40257857 — Europe PMC (en), https://europepmc.org/article/MED/40257857 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fd092c107ace (Metraipolis archive dc_fd092c107ace, sha256 351b11b654f648a1692b3389e6cdaed55b8e9d20f5d7f1a8c167ac2c0a22c00c)

BibTeX

@misc{dcfd092c107ace,
  title = {Per- and Polyfluoroalkyl Substances in Eutopic Endometrium Tissue and Risk of Endometriosis: Findings from the Investigating Mixtures of Pollutants and… — Europe PMC PMID:40257857},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40257857},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fd092c107ace; sha256 351b11b654f648a1692b3389e6cdaed55b8e9d20f5d7f1a8c167ac2c0a22c00c},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40257857. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Per- and polyfluoroalkyl substances (PFAS) exposure is widespread and has been linked with gynecologic disease. To our knowledge, no study has measured PFAS in endometrial tissue. Methods: Eutopic endometrial tissue specimens (n=434) were collected from Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) study participants undergoing laparoscopy or laparotomy for any indication (2007-2009). Nine PFAS were measured by high-performance liquid chromatography-tandem mass spectrometry [perfluorodecanoic acid (PFDA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorododecanoic acid (PFDoDA), perfluoroheptanoic acid (PFHpA), perfluorooctanesulfonamide (PFOSA), and perfluoroundecanoic acid (PFUnDA)]. Surgeons diagnosed endometriosis by gold-standard visualization and evaluated the endometriosis staging as moderate and severe (stages 3 and 4) compared to minimal and mild (stages 1 and 2) using American Society of Reproductive Medicine (ASRM) classification. We used modified Poisson regression models adjusted for age (continuous), race (white, all other race/ethnicities), smoking status (serum cotinine >10 ng/mL), study site (Utah, California), and body mass index (continuous) to obtain relative risks (RR) of endometriosis diagnosis and 95% confidence intervals (CIs) for each PFAS. PFAS mixtures were evaluated using Bayesian kernel machine regression. Results: Participants were, on average, 33±7 years old, and 75% of participants were non-Hispanic white. Of the 181 participants with an incident endometriosis diagnosis, 73% had ASRM stage 1 or 2, while 27% had stage 3 or 4. Median [interquartile range (IQR)] eutopic endometrium tissue levels, in nanograms per gram, were 6.58 (6.44) for PFOS, 1.93 (1.71) for PFOA, 0.65 (0.75) for PFHxS, 0.58 (0.52) for PFNA, and 0.12 (0.18) for PFOSA. PFAS in the endometrial tissue was not associated with endometriosis. However, select PFAS in the eutopic tissue were associated with a risk of more advanced (stage 3 or 4 vs. 1 or 2) endometriosis [PFOSA RR=1.25 (95% CI: 1.10, 1.43), PFHxS RR=1.37 (95% CI: 1.12, 1.68), PFOS RR=1.36 (95% CI: 1.02, 1.81)]. Conclusion: PFAS were widely detected in eutopic endometrial tissue. There was no evidence that PFAS in endometrial tissue were associated with a higher risk of endometriosis diagnosis. However, PFOS, PFOSA, and PFHxS in the endometrial tissue were associated with risk of more severe stage of endometriosis. https://doi.org/10.1289/EHP15852.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2025 (prima pubblicazione 2025-06-02).
Identificativi: PMID 40257857 · PMCID PMC12129303 · DOI 10.1289/ehp15852.
Descrittori MeSH principali: Endometrium; Endometriosis; Fluorocarbons; Environmental Pollutants; Environmental Exposure.
Pagina: https://europepmc.org/article/MED/40257857 — https://doi.org/10.1289/ehp15852. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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