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Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development — Europe PMC PMID:40834049

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40834049
DOI: 10.1371/journal.pgen.1011672
License (as archived): CC0-1.0
Archived: 2026-10-08T03:56:15.789Z
SHA-256 of the archived text: 453f1863b19a93ccaf97b18bb33cfdb0c7ee2712be1dc92bad3b178b0b4c686d
Stable URL of this page: https://metraipolis.com/documento/dc_fc882a6499bb

How to cite

Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development — Europe PMC PMID:40834049 — Europe PMC (en), https://europepmc.org/article/MED/40834049 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fc882a6499bb (Metraipolis archive dc_fc882a6499bb, sha256 453f1863b19a93ccaf97b18bb33cfdb0c7ee2712be1dc92bad3b178b0b4c686d)

BibTeX

@misc{dcfc882a6499bb,
  title = {Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development — Europe PMC PMID:40834049},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40834049},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fc882a6499bb; sha256 453f1863b19a93ccaf97b18bb33cfdb0c7ee2712be1dc92bad3b178b0b4c686d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40834049. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Neuromodulators and peptide hormones play important roles in regulating animal behavior. A well-studied example is ecdysis, which is used by insects to shed their exoskeleton at the end of each molt. Ecdysis is initiated by Ecdysis Triggering Hormone (ETH) and Eclosion Hormone (EH), which interact via positive feedback to coordinate the sequence of behavioral and physiological changes that cause exoskeleton shedding. Whereas the cell types targeted by ETH are well characterized, those targeted by EH have remained largely unknown due to limited characterization of the EH receptor (EHR). A gene encoding an EHR has been described in the oriental fruit fly, B. dorsalis, and in the desert locust, Schistocerca gregaria. However, little is known in these species about its expression pattern and its precise role at ecdysis, and no other insect EHRs are known. Here we analyze CG10738, the Drosophila ortholog of the B. dorsalis gene encoding EHR, and show that expressing it in cells confers sensitivity to EH. In addition, mutations of CG10738 specifically disrupt ecdysis, phenocopying the knockout of the EH gene. Together, these results indicate that CG10738 encodes the Drosophila EHR. As in B. dorsalis, EHR is expressed in the ETH-producing Inka cells; in addition, it is expressed in many known targets of ETH, including the neurons responsible for the secretion of other ecdysis-related peptides, such as CCAP and EH itself. Our results from targeted knockdown and rescue experiments reveal that EHR is required for ecdysis in diverse cell types and that the role of EHR in different targets differs with developmental stage. Our findings indicate extensive convergence of EH and ETH signaling and provide an exemplar of the complex mechanisms by which hormones control animal behavior.

Tema degli esploratori: ricerca e scienza aperta (ricerca Europe PMC «preprint», solo open access).
Pubblicazione: PLoS genetics, 2025 (prima pubblicazione 2025-08-20).
Identificativi: PMID 40834049 · PMCID PMC12393706 · DOI 10.1371/journal.pgen.1011672.
Descrittori MeSH principali: Drosophila; Insect Hormones; Drosophila Proteins; Molting.
Pagina: https://europepmc.org/article/MED/40834049 — https://doi.org/10.1371/journal.pgen.1011672. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T03:24:08.099Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.