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Sex-specific vagal and spinal modulation of breathing with chest compression — Europe PMC PMID:32555612

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32555612
DOI: 10.1371/journal.pone.0234193
License (as archived): CC0-1.0
Archived: 2026-11-08T10:38:00.577Z
SHA-256 of the archived text: 67424e02ab79dea992e742b55478a2c33d1bc66992eefb1643e9c0daa2952b86
Stable URL of this page: https://metraipolis.com/documento/dc_fc7fcaefbeb1

How to cite

Sex-specific vagal and spinal modulation of breathing with chest compression — Europe PMC PMID:32555612 — Europe PMC (en), https://europepmc.org/article/MED/32555612 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fc7fcaefbeb1 (Metraipolis archive dc_fc7fcaefbeb1, sha256 67424e02ab79dea992e742b55478a2c33d1bc66992eefb1643e9c0daa2952b86)

BibTeX

@misc{dcfc7fcaefbeb1,
  title = {Sex-specific vagal and spinal modulation of breathing with chest compression — Europe PMC PMID:32555612},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32555612},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fc7fcaefbeb1; sha256 67424e02ab79dea992e742b55478a2c33d1bc66992eefb1643e9c0daa2952b86},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32555612. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Lung volume is modulated by sensory afferent feedback via vagal and spinal pathways. The purpose of this study was to systematically alter afferent feedback with and without a mechanical challenge (chest compression). We hypothesized that manipulation of afferent feedback by nebulization of lidocaine, extra-thoracic vagotomy, or lidocaine administration to the pleural space would produce differential effects on the motor pattern of breathing during chest compression in sodium pentobarbital anesthetized rats (N = 43). Our results suggest that: 1) pulmonary stretch receptors are not the sole contributor to breathing feedback in adult male and female rats; 2) of our manipulations, chest compression had the largest effect on early expiratory diaphragm activity ("yield"); 3) reduction of spinally-mediated afferent feedback modulates breathing patterns most likely via inhibition; and 4) breathing parameters demonstrate large sex differences. Compared to males, female animals had lower respiratory rates (RR), which were further depressed by vagotomy, while chest compression increased RR in males, and decreased yield in females without changing RR. Collectively, our results suggest that balance between tonic vagal inhibition and spinal afferent feedback maintains breathing characteristics, and that it is important to specifically evaluate sex differences when studying control of breathing.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2020 (prima pubblicazione 2020-06-17).
Identificativi: PMID 32555612 · PMCID PMC7299359 · DOI 10.1371/journal.pone.0234193.
Descrittori MeSH principali: Respiration.
Pagina: https://europepmc.org/article/MED/32555612 — https://doi.org/10.1371/journal.pone.0234193. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-08T10:32:35.894Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.