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Immediate pools of malaria infections at diagnosis combined with targeted deep sequencing accurately quantifies frequency of drug resistance mutations — Europe PMC PMID:34820155

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34820155
DOI: 10.7717/peerj.11794
License (as archived): CC0-1.0
Archived: 2026-11-01T12:44:05.652Z
SHA-256 of the archived text: 8e79a32e3137d9e6ce21428428483741cdb2eaed9f1f78c8e4066b25db714112
Stable URL of this page: https://metraipolis.com/documento/dc_fb4be463aa2e

How to cite

Immediate pools of malaria infections at diagnosis combined with targeted deep sequencing accurately quantifies frequency of drug resistance mutations — Europe PMC PMID:34820155 — Europe PMC (en), https://europepmc.org/article/MED/34820155 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fb4be463aa2e (Metraipolis archive dc_fb4be463aa2e, sha256 8e79a32e3137d9e6ce21428428483741cdb2eaed9f1f78c8e4066b25db714112)

BibTeX

@misc{dcfb4be463aa2e,
  title = {Immediate pools of malaria infections at diagnosis combined with targeted deep sequencing accurately quantifies frequency of drug resistance mutations — Europe PMC PMID:34820155},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34820155},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fb4be463aa2e; sha256 8e79a32e3137d9e6ce21428428483741cdb2eaed9f1f78c8e4066b25db714112},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34820155. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Antimalarial resistance surveillance in sub-Saharan Africa is often constrained by logistical and financial challenges limiting its breadth and frequency. At two sites in Ghana, we have piloted a streamlined sample pooling process created immediately by sequential addition of positive malaria cases at the time of diagnostic testing. This streamlined process involving a single tube minimized clinical and laboratory work and provided accurate frequencies of all known drug resistance mutations after high-throughput targeted sequencing using molecular inversion probes. Our study validates this method as a cost-efficient, accurate and highly-scalable approach for drug resistance mutation monitoring that can potentially be applied to other infectious diseases such as tuberculosis.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PeerJ, 2021 (prima pubblicazione 2021-11-09).
Identificativi: PMID 34820155 · PMCID PMC8588852 · DOI 10.7717/peerj.11794.
Parole chiave degli autori: Drug resistance; Malaria; Plasmodium falciparum; Molecular Surveillance; Molecular Inversion Probes.
Pagina: https://europepmc.org/article/MED/34820155 — https://doi.org/10.7717/peerj.11794. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-01T12:37:31.996Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.