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The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci — Europe PMC PMID:34259624

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34259624
DOI: 10.7554/elife.67113
License (as archived): CC0-1.0
Archived: 2026-11-03T16:22:42.293Z
SHA-256 of the archived text: c4176796c779c42199380bfdd66299b50572310e87031dd3576b4543d283fc26
Stable URL of this page: https://metraipolis.com/documento/dc_fb26cbaffe84

How to cite

The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci — Europe PMC PMID:34259624 — Europe PMC (en), https://europepmc.org/article/MED/34259624 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_fb26cbaffe84 (Metraipolis archive dc_fb26cbaffe84, sha256 c4176796c779c42199380bfdd66299b50572310e87031dd3576b4543d283fc26)

BibTeX

@misc{dcfb26cbaffe84,
  title = {The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci — Europe PMC PMID:34259624},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34259624},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_fb26cbaffe84; sha256 c4176796c779c42199380bfdd66299b50572310e87031dd3576b4543d283fc26},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34259624. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn 916 -type and Tn 1207.1 -type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn 1207.1 -type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-β-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2021 (prima pubblicazione 2021-07-14).
Identificativi: PMID 34259624 · PMCID PMC8321556 · DOI 10.7554/elife.67113.
Parole chiave degli autori: Genetics; Recombination; Microbiology; Infectious disease; Genomics; Streptococcus pneumoniae; epidemiology; Amr.
Descrittori MeSH principali: Gene Transfer, Horizontal.
Pagina: https://europepmc.org/article/MED/34259624 — https://doi.org/10.7554/elife.67113. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-03T16:14:23.115Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.