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10β,17β-Dihydroxyestra-1,4-dien-3-one — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T15:53:23.046Z
SHA-256 of the archived text: 5e30e114f257cdb5c0c0615a061c769e660aef547f7f78f5d6f84523d8d3d307
Stable URL of this page: https://metraipolis.com/documento/dc_fa76e07dccdc

How to cite

10β,17β-Dihydroxyestra-1,4-dien-3-one — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_fa76e07dccdc (Metraipolis archive dc_fa76e07dccdc, sha256 5e30e114f257cdb5c0c0615a061c769e660aef547f7f78f5d6f84523d8d3d307)

BibTeX

@misc{dcfa76e07dccdc,
  title = {10β,17β-Dihydroxyestra-1,4-dien-3-one — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_fa76e07dccdc; sha256 5e30e114f257cdb5c0c0615a061c769e660aef547f7f78f5d6f84523d8d3d307},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED), also known as estradiol paraquinol, is an orally active, centrally selective estrogen and a biosynthetic prodrug of estradiol. Upon systemic administration, regardless of route of administration, DHED has been found to rapidly and selectively convert into estradiol in the brain, whereas no such conversion occurs in the rest of the body. Moreover, DHED itself possesses no estrogenic activity, requiring transformation into estradiol for its estrogenicity. As such, the drug shows selective estrogenic effects in the brain (e.g., alleviation of hot flashes, neuroprotection) that are said to be identical to those of estradiol, whereas estrogenic effects elsewhere in the body are not observed. DHED has been proposed as a possible novel estrogenic treatment for neurological and psychiatric conditions associated with hypoestrogenism (e.g., menopausal hot flashes, depression, cognitive decline, Alzheimer's disease, and stroke) that uniquely lacks potentially detrimental estrogenic side effects in the periphery.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «10β,17β-Dihydroxyestra-1,4-dien-3-one» — https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one
Wikidata Q30315171 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q30315171
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1369635188, consultata il 2026-10-07T15:26:57.174Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: b9ad89062c74bb67417da9d4f609da3a8df654fab38b577803ff6847804e6efa