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Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection — Europe PMC PMID:31821327

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31821327
DOI: 10.1371/journal.pone.0225611
License (as archived): CC0-1.0
Archived: 2026-11-09T23:23:28.733Z
SHA-256 of the archived text: d77d600cee9176be862b3a5e2c92616e584e4f4ec1609182dc2af0e3db152549
Stable URL of this page: https://metraipolis.com/documento/dc_f78ee86ae6ea

How to cite

Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection — Europe PMC PMID:31821327 — Europe PMC (en), https://europepmc.org/article/MED/31821327 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_f78ee86ae6ea (Metraipolis archive dc_f78ee86ae6ea, sha256 d77d600cee9176be862b3a5e2c92616e584e4f4ec1609182dc2af0e3db152549)

BibTeX

@misc{dcf78ee86ae6ea,
  title = {Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection — Europe PMC PMID:31821327},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31821327},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_f78ee86ae6ea; sha256 d77d600cee9176be862b3a5e2c92616e584e4f4ec1609182dc2af0e3db152549},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31821327. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Undernutrition, as described by low body mass index (BMI), is a foremost risk factor for the progression of active Tuberculosis (TB). Undernutrition is also known to impact the baseline frequencies of innate and adaptive immune cells in animal models. To verify whether undernutrition has any influence on the baseline frequencies of immune cells in latent Mycobacterium tuberculosis infection (LTBI), we examined the frequencies of T cell-, B cell, monocyte- and dendritic cell (DC)- subsets in individuals with LTBI and low BMI (LBMI) and contrasted them with LTBI and normal BMI (NBMI) groups. LBMI was characterized by decreased frequencies and absolute cell counts of T cells, B cells and NK cells in comparison with NBMI. LBMI individuals demonstrated significantly enhanced frequencies of naïve and effector CD4+ and CD8+ T cells and significantly decreased frequencies of central memory, effector memory CD4+ and CD8+ T cells and regulatory T cells. Among B cell subsets, LBMI individuals demonstrated significantly diminished frequencies of naïve, immature, classical memory, activated memory, atypical memory and plasma cells. In addition, LBMI individuals showed significantly decreased frequencies of classical monocytes, myeloid DCs and plasmacytoid DCs and significantly increased frequencies of intermediate and non-classical monocytes and myeloid derived suppressor cells. BMI exhibited a positive correlation with B cell and NK cell counts. Our data, therefore, demonstrates that coexistent undernutrition in LTBI is characterized by the occurrence of a significant modulation in the frequency of innate and adaptive immune cell subsets.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-12-10).
Identificativi: PMID 31821327 · PMCID PMC6903744 · DOI 10.1371/journal.pone.0225611.
Descrittori MeSH principali: Immunity, Cellular; Immunity, Innate.
Pagina: https://europepmc.org/article/MED/31821327 — https://doi.org/10.1371/journal.pone.0225611. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-09T23:20:21.422Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.