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A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression — Europe PMC PMID:35507386

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35507386
DOI: 10.7554/elife.75470
License (as archived): CC0-1.0
Archived: 2026-10-18T14:55:53.843Z
SHA-256 of the archived text: e43c9ece8155d8ae316072ddeafa4f85bc416feb5a0a466a38de68744d88256e
Stable URL of this page: https://metraipolis.com/documento/dc_efcb5d7ae7ca

How to cite

A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression — Europe PMC PMID:35507386 — Europe PMC (en), https://europepmc.org/article/MED/35507386 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_efcb5d7ae7ca (Metraipolis archive dc_efcb5d7ae7ca, sha256 e43c9ece8155d8ae316072ddeafa4f85bc416feb5a0a466a38de68744d88256e)

BibTeX

@misc{dcefcb5d7ae7ca,
  title = {A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression — Europe PMC PMID:35507386},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35507386},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_efcb5d7ae7ca; sha256 e43c9ece8155d8ae316072ddeafa4f85bc416feb5a0a466a38de68744d88256e},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35507386. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Food intake behavior is regulated by a network of appetite-inducing and appetite-suppressing neuronal populations throughout the brain. The parasubthalamic nucleus (PSTN), a relatively unexplored population of neurons in the posterior hypothalamus, has been hypothesized to regulate appetite due to its connectivity with other anorexigenic neuronal populations and because these neurons express Fos, a marker of neuronal activation, following a meal. However, the individual cell types that make up the PSTN are not well characterized, nor are their functional roles in food intake behavior. Here, we identify and distinguish between two discrete PSTN subpopulations, those that express tachykinin-1 (PSTN Tac1 neurons) and those that express corticotropin-releasing hormone (PSTN CRH neurons), and use a panel of genetically encoded tools in mice to show that PSTN Tac1 neurons play an important role in appetite suppression. Both subpopulations increase activity following a meal and in response to administration of the anorexigenic hormones amylin, cholecystokinin (CCK), and peptide YY (PYY). Interestingly, chemogenetic inhibition of PSTN Tac1 , but not PSTN CRH neurons, reduces the appetite-suppressing effects of these hormones. Consistently, optogenetic and chemogenetic stimulation of PSTN Tac1 neurons, but not PSTN CRH neurons, reduces food intake in hungry mice. PSTN Tac1 and PSTN CRH neurons project to distinct downstream brain regions, and stimulation of PSTN Tac1 projections to individual anorexigenic populations reduces food consumption. Taken together, these results reveal the functional properties and projection patterns of distinct PSTN cell types and demonstrate an anorexigenic role for PSTN Tac1 neurons in the hormonal and central regulation of appetite.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2022 (prima pubblicazione 2022-05-04).
Identificativi: PMID 35507386 · PMCID PMC9119672 · DOI 10.7554/elife.75470.
Parole chiave degli autori: Hypothalamus; Mouse; Feeding; Neuroscience; PSTN; Energy Homeostasis; Agrp; Parabrachial; Parasubthalamic.
Descrittori MeSH principali: Appetite; Appetite Regulation.
Pagina: https://europepmc.org/article/MED/35507386 — https://doi.org/10.7554/elife.75470. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-18T14:48:27.737Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.