Metraipolis › archive › dc_ef1de33797bb

Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States — Europe PMC PMID:34547028

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34547028
DOI: 10.1371/journal.pone.0249617
License (as archived): CC0-1.0
Archived: 2026-11-02T18:29:41.473Z
SHA-256 of the archived text: c47f6dc99711d67208731a148798b40e47ace82cededf96737bf97766ff882e1
Stable URL of this page: https://metraipolis.com/documento/dc_ef1de33797bb

How to cite

Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States — Europe PMC PMID:34547028 — Europe PMC (en), https://europepmc.org/article/MED/34547028 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ef1de33797bb (Metraipolis archive dc_ef1de33797bb, sha256 c47f6dc99711d67208731a148798b40e47ace82cededf96737bf97766ff882e1)

BibTeX

@misc{dcef1de33797bb,
  title = {Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States — Europe PMC PMID:34547028},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34547028},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ef1de33797bb; sha256 c47f6dc99711d67208731a148798b40e47ace82cededf96737bf97766ff882e1},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34547028. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Salmonella enterica subspecies enterica serotype Dublin is a host-adapted serotype in cattle, associated with enteritis and systemic disease. The primary clinical manifestation of Salmonella Dublin infection in cattle, especially calves, is respiratory disease. While rare in humans, it can cause severe illness, including bacteremia, with hospitalization and death. In the United States, S. Dublin has become one of the most multidrug-resistant serotypes. The objective of this study was to characterize S. Dublin isolates from sick cattle by analyzing phenotypic and genotypic antimicrobial resistance (AMR) profiles, the presence of plasmids, and phylogenetic relationships. S. Dublin isolates (n = 140) were selected from submissions to the NVSL for Salmonella serotyping (2014-2017) from 21 states. Isolates were tested for susceptibility against 14 class-representative antimicrobial drugs. Resistance profiles were determined using the ABRicate with Resfinder and NCBI databases, AMRFinder and PointFinder. Plasmids were detected using ABRicate with PlasmidFinder. Phylogeny was determined using vSNP. We found 98% of the isolates were resistant to more than 4 antimicrobials. Only 1 isolate was pan-susceptible and had no predicted AMR genes. All S. Dublin isolates were susceptible to azithromycin and meropenem. They showed 96% resistance to sulfonamides, 97% to tetracyclines, 95% to aminoglycosides and 85% to beta-lactams. The most common AMR genes were: sulf2 and tetA (98.6%), aph(6)-Id (97.9%), aph(3'')-Ib, (97.1%), floR (94.3%), and blaCMY-2 (85.7%). All quinolone resistant isolates presented mutations in gyrA. Ten plasmid types were identified among all isolates with IncA/C2, IncX1, and IncFII(S) being the most frequent. The S. Dublin isolates show low genomic genetic diversity. This study provided antimicrobial susceptibility and genomic insight into S. Dublin clinical isolates from cattle in the U.S. Further sequence analysis integrating food and human origin S. Dublin isolates may provide valuable insight on increased virulence observed in humans.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-09-21).
Identificativi: PMID 34547028 · PMCID PMC8454963 · DOI 10.1371/journal.pone.0249617.
Pagina: https://europepmc.org/article/MED/34547028 — https://doi.org/10.1371/journal.pone.0249617. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-02T18:22:08.108Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.