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Nuclear mitochondrial DNA segment — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-06T00:39:39.221Z
SHA-256 of the archived text: dbd0ef477d1f55adc1868af63ea814d46b1a615d836cf8d7a1bac6e130efcc45
Stable URL of this page: https://metraipolis.com/documento/dc_eeebfce8f030

How to cite

Nuclear mitochondrial DNA segment — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_eeebfce8f030 (Metraipolis archive dc_eeebfce8f030, sha256 dbd0ef477d1f55adc1868af63ea814d46b1a615d836cf8d7a1bac6e130efcc45)

BibTeX

@misc{dceeebfce8f030,
  title = {Nuclear mitochondrial DNA segment — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_eeebfce8f030; sha256 dbd0ef477d1f55adc1868af63ea814d46b1a615d836cf8d7a1bac6e130efcc45},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Nuclear mitochondrial DNA (NUMT) segments or genetic loci describe a transposition of any type of cytoplasmic mitochondrial DNA into the nuclear genome of eukaryotic organisms. More NUMT sequences of different sizes and lengths in the diverse number of eukaryotes have been detected as whole genome sequencing of different organisms accumulates. They have often been unintentionally discovered by researchers who were looking for mitochondrial DNA (mtDNA). NUMTs have been reported in all studied eukaryotes, and nearly all mitochondrial genome regions can be integrated into the nuclear genome. However, NUMTs differ in number and size across different species. Such differences may be accounted for by interspecific variation in such factors as germline stability and mitochondria number. After the release of the mtDNA into the cytoplasm, due to the mitochondrial alteration and morphological changes, it is transferred into the nucleus and inserted by double-stranded break repair processes into the nuclear DNA (nDNA). A correlation has been found between the fraction of noncoding DNA and NUMT abundance in the genome, and NUMTs are observed to have non-random distribution and a higher likelihood of being inserted in certain genomic regions. Depending on the location of the insertion, NUMTs might disrupt gene function. In addition, de novo integration of NUMT pseudogenes into the nuclear genome can have adverse effects.

Tema degli esploratori: calcolo e infrastrutture (deposito sistematico; ricerca «volunteer computing»).
Fonte: Wikipedia in inglese, voce «Nuclear mitochondrial DNA segment» — https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment
Wikidata Q7069705 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q7069705
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Nuclear_mitochondrial_DNA_segment?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1374076472, consultata il 2026-10-05T23:51:23.470Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: cc930cf72842a85e334b2b1f17807d629807122cdbc54dfb46baeddcbd007c33