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NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA — Europe PMC PMID:33835023

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33835023
DOI: 10.7554/elife.61880
License (as archived): CC0-1.0
Archived: 2026-11-05T01:27:21.386Z
SHA-256 of the archived text: 10186f8e3bc699722467ac3f679e9d0f0ea5885c919f20c488e0a60d400c6e0e
Stable URL of this page: https://metraipolis.com/documento/dc_edd00a94541d

How to cite

NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA — Europe PMC PMID:33835023 — Europe PMC (en), https://europepmc.org/article/MED/33835023 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_edd00a94541d (Metraipolis archive dc_edd00a94541d, sha256 10186f8e3bc699722467ac3f679e9d0f0ea5885c919f20c488e0a60d400c6e0e)

BibTeX

@misc{dcedd00a94541d,
  title = {NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA — Europe PMC PMID:33835023},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33835023},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_edd00a94541d; sha256 10186f8e3bc699722467ac3f679e9d0f0ea5885c919f20c488e0a60d400c6e0e},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33835023. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus subtilis . While NusA was known to function as an intrinsic termination factor in B. subtilis , the role of NusG in this process was unknown. To examine the individual and combinatorial roles that NusA and NusG play in intrinsic termination, Term-seq was conducted in wild type, NusA depletion, Δ nusG , and NusA depletion Δ nusG strains. We determined that NusG functions as an intrinsic termination factor that works alone and cooperatively with NusA to facilitate termination at 88% of the 1400 identified intrinsic terminators. Our results indicate that NusG stimulates a sequence-specific pause that assists in the completion of suboptimal terminator hairpins with weak terminal A-U and G-U base pairs at the bottom of the stem. Loss of NusA and NusG leads to global misregulation of gene expression and loss of NusG results in flagella and swimming motility defects.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2021 (prima pubblicazione 2021-04-09).
Identificativi: PMID 33835023 · PMCID PMC8060035 · DOI 10.7554/elife.61880.
Parole chiave degli autori: Biochemistry; B. subtilis; Microbiology; Gene regulation; Infectious disease; motility; Nusa; Transcription Termination; Chemical Biology; Nusg; Term-seq.
Descrittori MeSH principali: Gene Expression; Transcription Termination, Genetic.
Pagina: https://europepmc.org/article/MED/33835023 — https://doi.org/10.7554/elife.61880. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T01:23:46.787Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.