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GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line — Europe PMC PMID:38060571

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38060571
DOI: 10.1371/journal.pone.0293406
License (as archived): CC0-1.0
Archived: 2026-10-07T11:30:39.697Z
SHA-256 of the archived text: 7106512eb63dcb7ae206cd3fdcf6fbf47f06ba11bdaaf26a56c66126eadccb6d
Stable URL of this page: https://metraipolis.com/documento/dc_ec6e14754753

How to cite

GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line — Europe PMC PMID:38060571 — Europe PMC (en), https://europepmc.org/article/MED/38060571 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ec6e14754753 (Metraipolis archive dc_ec6e14754753, sha256 7106512eb63dcb7ae206cd3fdcf6fbf47f06ba11bdaaf26a56c66126eadccb6d)

BibTeX

@misc{dcec6e14754753,
  title = {GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line — Europe PMC PMID:38060571},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38060571},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ec6e14754753; sha256 7106512eb63dcb7ae206cd3fdcf6fbf47f06ba11bdaaf26a56c66126eadccb6d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38060571. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The AGMK1-9T7 cell line has been used to study neoplasia in tissue culture. By passage in cell culture, these cells evolved to become tumorigenic and metastatic in immunodeficient mice at passage 40. Of the 20 x 106 kidney cells originally plated, less than 2% formed the colonies that evolved to create this cell line. These cells could be the progeny of some type of kidney progenitor cells. To characterize these cells, we documented their renal lineage by their expression of PAX-2 and MIOX, detected by indirect immunofluorescence. These cells assessed by flow-cytometry expressed high levels of CD44, CD73, CD105, Sca-1, and GLI1 across all passages tested; these markers have been reported to be expressed by renal progenitor cells. The expression of GLI1 was confirmed by immunofluorescence and western blot analysis. Cells from passages 13 to 23 possessed the ability to differentiate into adipocytes, osteoblasts, and chondrocytes; after passage 23, their ability to form these cell types was lost. These data indicate that the cells that formed the AGMK1-9T7 cell line were GLI1+ perivascular, kidney, progenitor cells.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-12-07).
Identificativi: PMID 38060571 · PMCID PMC10703308 · DOI 10.1371/journal.pone.0293406.
Descrittori MeSH principali: Mesenchymal Stem Cells; Neoplasms.
Pagina: https://europepmc.org/article/MED/38060571 — https://doi.org/10.1371/journal.pone.0293406. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T11:17:30.985Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.