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Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model — Europe PMC PMID:33439896

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33439896
DOI: 10.1371/journal.pone.0241682
License (as archived): CC0-1.0
Archived: 2026-11-06T09:04:22.929Z
SHA-256 of the archived text: 4313238980e197a1c1c2c432419b1acabd7738994c21bc17edb5f0e27d1c0ebc
Stable URL of this page: https://metraipolis.com/documento/dc_ebceae9bca7e

How to cite

Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model — Europe PMC PMID:33439896 — Europe PMC (en), https://europepmc.org/article/MED/33439896 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ebceae9bca7e (Metraipolis archive dc_ebceae9bca7e, sha256 4313238980e197a1c1c2c432419b1acabd7738994c21bc17edb5f0e27d1c0ebc)

BibTeX

@misc{dcebceae9bca7e,
  title = {Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model — Europe PMC PMID:33439896},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33439896},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ebceae9bca7e; sha256 4313238980e197a1c1c2c432419b1acabd7738994c21bc17edb5f0e27d1c0ebc},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33439896. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Numerical body models of children are used for designing medical devices, including but not limited to optical imaging, ultrasound, CT, EEG/MEG, and MRI. These models are used in many clinical and neuroscience research applications, such as radiation safety dosimetric studies and source localization. Although several such adult models have been reported, there are few reports of full-body pediatric models, and those described have several limitations. Some, for example, are either morphed from older children or do not have detailed segmentations. Here, we introduce a 29-month-old male whole-body native numerical model, "MARTIN", that includes 28 head and 86 body tissue compartments, segmented directly from the high spatial resolution MRI and CT images. An advanced auto-segmentation tool was used for the deep-brain structures, whereas 3D Slicer was used to segment the non-brain structures and to refine the segmentation for all of the tissue compartments. Our MARTIN model was developed and validated using three separate approaches, through an iterative process, as follows. First, the calculated volumes, weights, and dimensions of selected structures were adjusted and confirmed to be within 6% of the literature values for the 2-3-year-old age-range. Second, all structural segmentations were adjusted and confirmed by two experienced, sub-specialty certified neuro-radiologists, also through an interactive process. Third, an additional validation was performed with a Bloch simulator to create synthetic MR image from our MARTIN model and compare the image contrast of the resulting synthetic image with that of the original MRI data; this resulted in a "structural resemblance" index of 0.97. Finally, we used our model to perform pilot MRI safety simulations of an Active Implantable Medical Device (AIMD) using a commercially available software platform (Sim4Life), incorporating the latest International Standards Organization guidelines. This model will be made available on the Athinoula A. Martinos Center for Biomedical Imaging website.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-01-13).
Identificativi: PMID 33439896 · PMCID PMC7806143 · DOI 10.1371/journal.pone.0241682.
Descrittori MeSH principali: Magnetic Resonance Imaging; Safety; Algorithms; Computer Simulation; Software.
Pagina: https://europepmc.org/article/MED/33439896 — https://doi.org/10.1371/journal.pone.0241682. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-06T08:59:58.698Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.