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High pyocyanin production and non-motility of Pseudomonas aeruginosa isolates are correlated with septic shock or death in bacteremic patients — Europe PMC PMID:34115807

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34115807
DOI: 10.1371/journal.pone.0253259
License (as archived): CC0-1.0
Archived: 2026-11-04T03:08:25.580Z
SHA-256 of the archived text: 7930b5521ff9d9fc90ec26e7b17bb54fa1cce72df0db38c5640f5ebc8a52d507
Stable URL of this page: https://metraipolis.com/documento/dc_eb82be656164

How to cite

High pyocyanin production and non-motility of Pseudomonas aeruginosa isolates are correlated with septic shock or death in bacteremic patients — Europe PMC PMID:34115807 — Europe PMC (en), https://europepmc.org/article/MED/34115807 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_eb82be656164 (Metraipolis archive dc_eb82be656164, sha256 7930b5521ff9d9fc90ec26e7b17bb54fa1cce72df0db38c5640f5ebc8a52d507)

BibTeX

@misc{dceb82be656164,
  title = {High pyocyanin production and non-motility of Pseudomonas aeruginosa isolates are correlated with septic shock or death in bacteremic patients — Europe PMC PMID:34115807},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34115807},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_eb82be656164; sha256 7930b5521ff9d9fc90ec26e7b17bb54fa1cce72df0db38c5640f5ebc8a52d507},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34115807. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Studies of the outcome of Pseudomonas aeruginosa bacteremia (Pab) have focused mainly on antibiotic appropriateness. However, P. aeruginosa possesses many virulence factors whose roles in outcomes have not been examined in humans, except for the type III secretion system (T3SS) toxins. The purpose of this study was to examine the role of virulence factors other than the T3SS toxins. Bacterial isolates were collected from 75 patients who suffered from Pa blood stream infections. Host factors such as neutropenia, immunosuppression, comorbidities, time to effective antibiotics, source of bacteremia, and presence of multidrug resistant (MDR) isolate were studied. The isolates were analyzed for the presence of toxin genes, proteolytic activity, swimming and twitching motility, and pyocyanin production. The data were analyzed to ascertain which virulence factors correlated with poor outcomes defined as septic shock or death (SS) within 7 days. Septic shock or death occurred in 25/75 patients. Univariate analysis identified age as a host factor that exerted a significant effect on these outcomes. Ineffective antibiotics administered during the first 24 hours of treatment or MDR P. aeruginosa did not influence the frequency of SS, nor did the presence of lasB, exoA, exoS exoU, plcH genes and proteolytic activity. However, 6/8 patients infected with non-motile isolates, developed SS, p = 0.014 and 5/6 isolates that produced large amounts of pyocyanin (>18ug/ml), were associated with SS, p = 0.014. Multivariate analysis indicated that the odds ratio (OR) for development of SS with a non-motile isolate was 6.8, with a 95% confidence interval (CI) (1.37, 51.5), p = 0.030 and with high pyocyanin producing isolates, an OR of 16.9, 95% CI = (2.27, 360), p = .017. This study evaluating the role of microbial factors that significantly effect outcomes following Pa bloodstream infection suggests that P. aeruginosa strains showing high pyocyanin production and the lack of motility independently increase the risk of SS.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-06-11).
Identificativi: PMID 34115807 · PMCID PMC8195364 · DOI 10.1371/journal.pone.0253259.
Pagina: https://europepmc.org/article/MED/34115807 — https://doi.org/10.1371/journal.pone.0253259. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-04T02:59:46.736Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.