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AdipoRon — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/AdipoRon
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-07T14:29:20.739Z
SHA-256 of the archived text: 3bd9befe36d1cefcfe03941b5daab7fd1aeffc3afe4c7b4fcfd47030e320b946
Stable URL of this page: https://metraipolis.com/documento/dc_eb75fc6ca4fd

How to cite

AdipoRon — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/AdipoRon (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_eb75fc6ca4fd (Metraipolis archive dc_eb75fc6ca4fd, sha256 3bd9befe36d1cefcfe03941b5daab7fd1aeffc3afe4c7b4fcfd47030e320b946)

BibTeX

@misc{dceb75fc6ca4fd,
  title = {AdipoRon — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/AdipoRon},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_eb75fc6ca4fd; sha256 3bd9befe36d1cefcfe03941b5daab7fd1aeffc3afe4c7b4fcfd47030e320b946},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/AdipoRon. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

AdipoRon is a selective, orally active, synthetic small-molecule agonist of the adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) (Kd = 1.8 μM and 3.1 μM, respectively). It activates AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in db/db mice (an animal model for type II diabetes and obesity). Moreover, AdipoRon has been found to extend the lifespans of db/db mice fed a high-fat diet, as well as improve exercise endurance. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and a panoply of other conditions. In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of physical exercise. Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating disorders, neurodegenerative disorders, and various other neuropsychiatric disorders. Also, it has been determined that exercise improves insulin resistance via activation of AdipoR1. As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. Moreover, it has been suggested they could potentially be used as a substitute for exercise to achieve similar physical and mental health benefits. In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1, AdipoR2, and AdipoRon identification data, as accused by an anonymous person/group called Ordinary_researchers.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «AdipoRon» — https://en.wikipedia.org/wiki/AdipoRon
Wikidata Q25100509: «composto chimico» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q25100509
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/AdipoRon?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1383705602, consultata il 2026-11-07T14:25:13.253Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 6918874c317c525877bf97a4b6b4f66270c93ff87ec179bdb5b3d1f038da784d