Metraipolis › archive › dc_ea899fc16315

ALS — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/ALS
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T19:11:07.123Z
SHA-256 of the archived text: b84823a3517b719dbace494b68c3a7c756cf8e3b4c4aab22a801e9e615abb676
Stable URL of this page: https://metraipolis.com/documento/dc_ea899fc16315

How to cite

ALS — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/ALS (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_ea899fc16315 (Metraipolis archive dc_ea899fc16315, sha256 b84823a3517b719dbace494b68c3a7c756cf8e3b4c4aab22a801e9e615abb676)

BibTeX

@misc{dcea899fc16315,
  title = {ALS — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/ALS},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_ea899fc16315; sha256 b84823a3517b719dbace494b68c3a7c756cf8e3b4c4aab22a801e9e615abb676},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/ALS. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), Lou Gehrig's disease or Charcot's disease (English: shar-KOH, French: [ʃaʁko]), is a rare terminal neurodegenerative disease defined by the progressive loss of both upper and lower motor neurons that normally control voluntary muscle contraction. ALS is the most common of the motor neuron diseases. ALS often presents with gradual muscle stiffness, twitches, weakness, and wasting. Motor neuron loss typically continues until the ability to eat, speak, move, and breathe without mechanical support is lost. At least 50% of people with ALS experience significant changes in thinking and behavior, with 15% of individuals going on to develop frontotemporal dementia. An ALS diagnosis is made based on a person's signs and symptoms, with additional testing conducted to rule out other potential causes. Depending on which areas of the body are affected first, ALS may be classified as limb-onset (beginning with weakness in the arms or legs) or bulbar-onset (beginning with difficulty in speaking or swallowing). Respiratory onset occurs in approximately 1–3% of cases. Most cases of ALS (about 90–95%) have no known cause and are known as sporadic ALS. Genetic, autoimmune, and environmental factors are believed to be involved in the onset of ALS. Approximately 5–10% of ALS cases have a known genetic cause and are often linked to a family history of ALS; such cases are known as familial ALS or hereditary ALS. Mutations in the C9orf72 gene are the most common known genetic cause of familial ALS and are also found in a subset of sporadic cases. Four disease-linked genes are responsible for approximately half of all genetic cases. There is no known cure for ALS. The goal of treatment is to slow the disease progression and improve symptoms. FDA-approved treatments that slow the progression of ALS include riluzole and edaravone. Non-invasive ventilation may result in both improved quality and length of life. Mechanical ventilation can prolong survival but does not stop disease progression. A feeding tube may help maintain weight and nutrition. Death is usually caused by respiratory failure. The disease can affect people of any age, but usually starts around the age of 60. The average survival from onset to death is two to four years, though this can vary; about 10% of those affected survive longer than ten years. Descriptions of the disease date back to at least 1824 by Charles Bell. In 1869, the connection between the symptoms and the underlying neurological problems was first described by French neurologist Jean-Martin Charcot, who in 1874 began using the term amyotrophic lateral sclerosis.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; ricerca «epidemiology»).
Fonte: Wikipedia in inglese, voce «ALS» — https://en.wikipedia.org/wiki/ALS
Wikidata Q206901 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q206901
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/ALS?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1378573400, consultata il 2026-10-07T18:34:16.606Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: de8a737db83e4b503f77f7c77b4d04d5619f5043262f7374dad6397b9fb9fe24