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Emx2 regulates hair cell rearrangement but not positional identity within neuromasts — Europe PMC PMID:33377867

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33377867
DOI: 10.7554/elife.60432
License (as archived): CC0-1.0
Archived: 2026-11-06T12:00:26.798Z
SHA-256 of the archived text: 58ff85ab19af19042539d989c642807a6ffd1f0076d5706103aec8beb5377a1d
Stable URL of this page: https://metraipolis.com/documento/dc_ea2bda7185de

How to cite

Emx2 regulates hair cell rearrangement but not positional identity within neuromasts — Europe PMC PMID:33377867 — Europe PMC (en), https://europepmc.org/article/MED/33377867 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ea2bda7185de (Metraipolis archive dc_ea2bda7185de, sha256 58ff85ab19af19042539d989c642807a6ffd1f0076d5706103aec8beb5377a1d)

BibTeX

@misc{dcea2bda7185de,
  title = {Emx2 regulates hair cell rearrangement but not positional identity within neuromasts — Europe PMC PMID:33377867},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33377867},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ea2bda7185de; sha256 58ff85ab19af19042539d989c642807a6ffd1f0076d5706103aec8beb5377a1d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33377867. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of opposite hair bundle orientations. Previously, we showed that transcription factor Emx2, expressed in only one of the daughter HCs, generates this bidirectional HC pattern (Jiang et al., 2017). Here, we asked whether Emx2 mediates this effect by changing location of hair bundle establishment or positions of HCs since daughter HCs are known to switch positions with each other. We showed this HC rearrangement, redefined as two processes named Rock and Roll, is required for positional acquisition of HCs. Apical protrusion formation of nascent HCs and planar polarity signaling are both important for the Rock and Roll. Emx2 facilitates Rock and Roll by delaying apical protrusion of its nascent HCs but it does not determine HCs' ultimate positions, indicating that Emx2 mediates bidirectional HC pattern by changing the location where hair bundle is established in HCs.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2020 (prima pubblicazione 2020-12-30).
Identificativi: PMID 33377867 · PMCID PMC7806267 · DOI 10.7554/elife.60432.
Parole chiave degli autori: Zebrafish; Transcription factors; Lateral line; developmental biology; Hair Bundle; Planar Polarity; Stereociliary Bundle.
Pagina: https://europepmc.org/article/MED/33377867 — https://doi.org/10.7554/elife.60432. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-06T11:56:53.072Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.