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Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer — Europe PMC PMID:40209106

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40209106
DOI: 10.1289/ehp14849
License (as archived): CC0-1.0
Archived: 2026-10-06T10:15:45.740Z
SHA-256 of the archived text: 6730cd45f5bedd3f106104e3bf24fbf03218092d6acc0e04c83febdf63e8ade7
Stable URL of this page: https://metraipolis.com/documento/dc_e8e417536679

How to cite

Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer — Europe PMC PMID:40209106 — Europe PMC (en), https://europepmc.org/article/MED/40209106 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_e8e417536679 (Metraipolis archive dc_e8e417536679, sha256 6730cd45f5bedd3f106104e3bf24fbf03218092d6acc0e04c83febdf63e8ade7)

BibTeX

@misc{dce8e417536679,
  title = {Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer — Europe PMC PMID:40209106},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40209106},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_e8e417536679; sha256 6730cd45f5bedd3f106104e3bf24fbf03218092d6acc0e04c83febdf63e8ade7},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40209106. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Pediatric thyroid cancer incidence has been increasing globally, with environmental exposures being a hypothesized risk factor. Objective: We evaluated the association between pediatric thyroid cancer risk and perinatal exposure to ambient fine particulate matter (PM) with aerodynamic diameter ≤2.5μm (PM2.5) and outdoor artificial light at night (O-ALAN). Both are considered environmental carcinogens with evidence of thyroid function disruption, reported associations with thyroid cancer in adults, and concerns of distributive inequity. O-ALAN may also serve as a proxy for other outdoor air pollutants or urbanization. Methods: We conducted a case-control study of papillary thyroid cancer nested within a California birth cohort that included 736 cases diagnosed at 0-19 y of age and born in 1982-2011 and 36,800 controls frequency-matched on birth year. We assigned individual-level exposures for residence at birth for ambient PM2.5 concentrations from a validated, ensemble-based prediction model and O-ALAN using the New World Atlas of Artificial Night Sky Brightness. We calculated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusting for potential confounders and stratified by age and race/ethnicity. Results: We observed statistically significant associations between PM2.5 exposure and papillary thyroid cancer risk overall (OR per 10-μg/m3 increase in PM2.5=1.07, 95% CI: 1.01, 1.14), among the 15-19 y age group (OR=1.08; 95% CI: 1.00, 1.16), and among Hispanic children (OR=1.13; 95% CI: 1.02, 1.24). For O-ALAN, we observed statistically significantly increased odds of papillary thyroid cancer in higher exposure tertiles in comparison with the reference tertile in the overall population (tertile 2: OR=1.25, 95% CI: 1.04, 1.50; tertile 3: OR=1.23, 95% CI: 1.02, 1.50) and when modeled as a continuous variable (OR=1.07 per 1 mcd/m2). In age-stratified analyses, significant associations were observed among the 15-19 y age group, but not the 0-14 y age group. No significant differences were found by race/ethnicity. Discussion: This study provides new evidence suggesting associations between early-life exposure to PM2.5 and O-ALAN and pediatric papillary thyroid cancer. Given that O-ALAN may also represent other air pollutants or broader urbanization patterns, further research and refinements to exposure metrics are needed to disentangle these factors. https://doi.org/10.1289/EHP14849.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2025 (prima pubblicazione 2025-05-29).
Identificativi: PMID 40209106 · PMCID PMC12121722 · DOI 10.1289/ehp14849.
Descrittori MeSH principali: Thyroid Neoplasms; Prenatal Exposure Delayed Effects; Air Pollutants; Lighting; Environmental Exposure; Particulate Matter.
Pagina: https://europepmc.org/article/MED/40209106 — https://doi.org/10.1289/ehp14849. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:45:27.528Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.