Metraipolis › archive › dc_e4298fa18ebf

(R)-69 — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/(R)-69
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-06T11:39:42.859Z
SHA-256 of the archived text: e33b67bad090ff714d58530c30575b9d6f0f6e93c7b711b294bff4695103e280
Stable URL of this page: https://metraipolis.com/documento/dc_e4298fa18ebf

How to cite

(R)-69 — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/(R)-69 (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_e4298fa18ebf (Metraipolis archive dc_e4298fa18ebf, sha256 e33b67bad090ff714d58530c30575b9d6f0f6e93c7b711b294bff4695103e280)

BibTeX

@misc{dce4298fa18ebf,
  title = {(R)-69 — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/(R)-69},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_e4298fa18ebf; sha256 e33b67bad090ff714d58530c30575b9d6f0f6e93c7b711b294bff4695103e280},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/(R)-69. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

(R)-69 (3IQ) is a drug of the tetrahydropyridinylpyrrolopyridine family related to the psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with 4.6-fold selectivity over 5-HT2B and 49-fold selectivity over 5-HT2C. It has a 5-HT2A Ki of 680 nM and an EC50 of 41 nM. (R)-69 is a biased agonist selective for activation of the Gq coupled signalling pathway, with much weaker activation of the β-arrestin 2 coupled pathway. In animal studies it produces antidepressant-like activity but without producing the head-twitch response associated with psychedelic effects. The drug was identified along with its close analogue (R)-70 via an ultra-large-scale docking campaign against the serotonin 5-HT2A receptor and was first described by Bryan L. Roth and colleagues in 2022. A number of related derivatives have also been developed.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «(R)-69» — https://en.wikipedia.org/wiki/(R)-69
Wikidata Q115111410 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q115111410
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/(R)-69?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1356175667, consultata il 2026-10-06T10:03:05.115Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: ca7eebf3aea56392eb45006409e3231b313890126540f56dc12b234fe3310351