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Host population dynamics influence Leptospira spp. transmission patterns among Rattus norvegicus in Boston, Massachusetts, US — Europe PMC PMID:40233129

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40233129
DOI: 10.1371/journal.pntd.0012966
License (as archived): CC0-1.0
Archived: 2026-10-06T11:31:01.475Z
SHA-256 of the archived text: 5cad8bcdb2299d88aba14d42d271af2610f278da4b4eb07cb05f3f4e1a615b80
Stable URL of this page: https://metraipolis.com/documento/dc_e28ef212db69

How to cite

Host population dynamics influence Leptospira spp. transmission patterns among Rattus norvegicus in Boston, Massachusetts, US — Europe PMC PMID:40233129 — Europe PMC (en), https://europepmc.org/article/MED/40233129 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_e28ef212db69 (Metraipolis archive dc_e28ef212db69, sha256 5cad8bcdb2299d88aba14d42d271af2610f278da4b4eb07cb05f3f4e1a615b80)

BibTeX

@misc{dce28ef212db69,
  title = {Host population dynamics influence Leptospira spp. transmission patterns among Rattus norvegicus in Boston, Massachusetts, US — Europe PMC PMID:40233129},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40233129},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_e28ef212db69; sha256 5cad8bcdb2299d88aba14d42d271af2610f278da4b4eb07cb05f3f4e1a615b80},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40233129. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Leptospirosis (caused by pathogenic bacteria in the genus Leptospira) is prevalent worldwide but more common in tropical and subtropical regions. Transmission can occur following direct exposure to infected urine from reservoir hosts, or a urine-contaminated environment, which then can serve as an infection source for additional rats and other mammals, including humans. The brown rat, Rattus norvegicus, is an important reservoir of Leptospira spp. in urban settings. We investigated the presence of Leptospira spp. among brown rats in Boston, Massachusetts and hypothesized that rat population dynamics in this urban setting influence the transportation, persistence, and diversity of Leptospira spp. We analyzed DNA from 328 rat kidney samples collected from 17 sites in Boston over a seven-year period (2016-2022); 59 rats representing 12 of 17 sites were positive for Leptospira spp. We used 21 neutral microsatellite loci to genotype 311 rats and utilized the resulting data to investigate genetic connectivity among sampling sites. We generated whole genome sequences for 28 Leptospira spp. isolates obtained from frozen and fresh tissue from some of the 59 positive rat kidneys. When isolates were not obtained, we attempted genomic DNA capture and enrichment, which yielded 14 additional Leptospira spp. genomes from rats. We also generated an enriched Leptospira spp. genome from a 2018 human case in Boston. We found evidence of high genetic structure among rat populations that is likely influenced by major roads and/or other dispersal barriers, resulting in distinct rat population groups within the city; at certain sites these groups persisted for multiple years. We identified multiple distinct phylogenetic clades of L. interrogans among rats that were tightly linked to distinct rat populations. This pattern suggests L. interrogans persists in local rat populations and its transportation is influenced by rat population dynamics. Finally, our genomic analyses of the Leptospira spp. detected in the 2018 human leptospirosis case in Boston suggests a link to rats as the source. These findings will be useful for guiding rat control and human leptospirosis mitigation efforts in this and other similar urban settings.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS neglected tropical diseases, 2025 (prima pubblicazione 2025-04-15).
Identificativi: PMID 40233129 · PMCID PMC12047771 · DOI 10.1371/journal.pntd.0012966.
Descrittori MeSH principali: Leptospira; Leptospirosis; Rodent Diseases; Disease Reservoirs.
Pagina: https://europepmc.org/article/MED/40233129 — https://doi.org/10.1371/journal.pntd.0012966. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:52:30.191Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.