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Anaphase-promoting complex — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Anaphase-promoting_complex
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-09T01:05:40.575Z
SHA-256 of the archived text: f0dab784fb4c43b627da748d59c2403f5aac78ff91c99d9a29cbf978ab3046fb
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Anaphase-promoting complex — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Anaphase-promoting_complex (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_df00c8dab0ee (Metraipolis archive dc_df00c8dab0ee, sha256 f0dab784fb4c43b627da748d59c2403f5aac78ff91c99d9a29cbf978ab3046fb)

BibTeX

@misc{dcdf00c8dab0ee,
  title = {Anaphase-promoting complex — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Anaphase-promoting_complex},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_df00c8dab0ee; sha256 f0dab784fb4c43b627da748d59c2403f5aac78ff91c99d9a29cbf978ab3046fb},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Anaphase-promoting_complex. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved. It was the discovery of the APC/C (and SCF) and their key role in eukaryotic cell-cycle regulation that established the importance of ubiquitin-mediated proteolysis in cell biology. Once perceived as a system exclusively involved in removing damaged protein from the cell, ubiquitination and subsequent protein degradation by the proteasome is now perceived as a universal regulatory mechanism for signal transduction whose importance approaches that of protein phosphorylation. In 2014, the APC/C was mapped in 3D at a resolution of less than a nanometre, which also uncovered its secondary structure. This finding could improve understanding of cancer and reveal new binding sites for future cancer drugs.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Anaphase-promoting complex» — https://en.wikipedia.org/wiki/Anaphase-promoting_complex
Wikidata Q418432: «ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q418432
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Anaphase-promoting_complex?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1351944745, consultata il 2026-11-09T00:59:51.155Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 5522d807b84a4440faed98fcad961cd5dbdcf05dd58480c8de28efce1635c5f4