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Atherosclerosis — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Atherosclerosis
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-10T06:11:01.745Z
SHA-256 of the archived text: 3d4ad3779c9708544496828f0e9b553034f677655a003387036fafa74851a75c
Stable URL of this page: https://metraipolis.com/documento/dc_dd571e7fa447

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Atherosclerosis — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Atherosclerosis (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_dd571e7fa447 (Metraipolis archive dc_dd571e7fa447, sha256 3d4ad3779c9708544496828f0e9b553034f677655a003387036fafa74851a75c)

BibTeX

@misc{dcdd571e7fa447,
  title = {Atherosclerosis — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Atherosclerosis},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_dd571e7fa447; sha256 3d4ad3779c9708544496828f0e9b553034f677655a003387036fafa74851a75c},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Atherosclerosis. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by the development of atheromatous plaques in the walls of arteries. This is a chronic inflammatory disease involving many different cell types and is driven by elevated blood levels of cholesterol, primarily LDL. These lesions lead to narrowing of the arteries. At the onset, there are usually no symptoms, but if they develop, symptoms generally begin around middle age. In severe cases, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney disorders, depending on the body part(s) in which the affected arteries are located. The exact cause of atherosclerosis is unknown and is proposed to be multifactorial. Risk factors include abnormal cholesterol levels, elevated levels of inflammatory biomarkers, high blood pressure, diabetes, smoking (both active and passive smoking), obesity, genetic factors, family history, lifestyle habits, and an unhealthy diet. Plaque is made up of fat, cholesterol, immune cells, calcium, and other substances found in the blood. The narrowing of arteries limits the flow of oxygen-rich blood to parts of the body. Diagnosis is based upon a physical exam, electrocardiogram, and exercise stress test, among others, depending on the affected artery or arteries. Prevention guidelines include eating a healthy diet, exercising, not smoking, and maintaining a normal body weight. Treatment of established atherosclerotic disease may include medications to lower cholesterol such as statins, blood pressure medication, and anticoagulant therapies to reduce the risk of blood clot formation. As the disease state progresses, more invasive strategies are applied, such as percutaneous coronary intervention, coronary artery bypass graft, or carotid endarterectomy. In some individuals, genetic factors are also implicated in the disease process and cause a strongly increased predisposition to development of atherosclerosis. Atherosclerosis generally starts when a person is young and worsens with age. Almost all people are affected to some degree by the age of 65. It is the number one cause of death and disability in developed countries. Though it was first described in 1575, there is evidence suggesting that this disease state is genetically inherent in the broader human population, with its origins tracing back to CMAH genetic mutations that may have occurred more than two million years ago during the evolution of hominin ancestors of modern human beings.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Atherosclerosis» — https://en.wikipedia.org/wiki/Atherosclerosis
Wikidata Q12252367: «malattia vascolare cronica e progressiva che si manifesta tipicamente nell'età adulta o avanzata» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q12252367
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Atherosclerosis?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1382893266, consultata il 2026-11-10T06:07:56.579Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: d437f4a44e54138de9a831927cde067e16f1ee7d78946cc5c5503e4bc2d1fbd2