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The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus — Europe PMC PMID:40029854

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40029854
DOI: 10.1371/journal.pone.0315766
License (as archived): CC0-1.0
Archived: 2026-10-06T13:18:02.874Z
SHA-256 of the archived text: 67af4d51739dc173c208e2673bf577b696d334afc5a83a2f6abf1d2861c34a28
Stable URL of this page: https://metraipolis.com/documento/dc_dc48a7eeba01

How to cite

The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus — Europe PMC PMID:40029854 — Europe PMC (en), https://europepmc.org/article/MED/40029854 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_dc48a7eeba01 (Metraipolis archive dc_dc48a7eeba01, sha256 67af4d51739dc173c208e2673bf577b696d334afc5a83a2f6abf1d2861c34a28)

BibTeX

@misc{dcdc48a7eeba01,
  title = {The putative forkhead transcription factor FhpA is necessary for development, aflatoxin production, and stress response in Aspergillus flavus — Europe PMC PMID:40029854},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40029854},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_dc48a7eeba01; sha256 67af4d51739dc173c208e2673bf577b696d334afc5a83a2f6abf1d2861c34a28},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40029854. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Forkhead transcription factors regulate several important biological processes in many eukaryotic species including fungi. Bioinformatic analysis of the Aspergillus flavus genome revealed four putative forkhead transcription factor genes. Genetic disruption of (AFLA_005634), a homolog of the Aspergillus nidulans fhpA/fkhA gene (AN4521), revealed that the fhpA gene is a negative regulator of both asexual spore production and aflatoxin B1 production in A. flavus. Furthermore, disruption of the fhpA gene caused a complete loss of sclerotial formation. Overexpression of the fhpA gene caused A. flavus to become more sensitive to sodium chloride whereas disruption of the fhpA gene did not change the ability of A. flavus to respond to any osmotic stress agent tested. Interestingly, both disruption and overexpression of the fhpA gene led to increases in sensitivity to the oxidative stress agent menadione. Overall, these results suggest that fhpA is an important regulator of morphological and chemical development in addition to stress response in A. flavus.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-03-03).
Identificativi: PMID 40029854 · PMCID PMC11875336 · DOI 10.1371/journal.pone.0315766.
Descrittori MeSH principali: Aspergillus flavus; Fungal Proteins; Aflatoxins; Aflatoxin B1; Forkhead Transcription Factors; Stress, Physiological.
Pagina: https://europepmc.org/article/MED/40029854 — https://doi.org/10.1371/journal.pone.0315766. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T11:32:36.110Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.