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Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain — Europe PMC PMID:34516550

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34516550
DOI: 10.1371/journal.pgen.1009794
License (as archived): CC0-1.0
Archived: 2026-11-02T20:51:10.228Z
SHA-256 of the archived text: e190f149d167ae54b1669b15b3b30c84414c501c73bef154ae3f5a59d7bd89a7
Stable URL of this page: https://metraipolis.com/documento/dc_da658ea06979

How to cite

Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain — Europe PMC PMID:34516550 — Europe PMC (en), https://europepmc.org/article/MED/34516550 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_da658ea06979 (Metraipolis archive dc_da658ea06979, sha256 e190f149d167ae54b1669b15b3b30c84414c501c73bef154ae3f5a59d7bd89a7)

BibTeX

@misc{dcda658ea06979,
  title = {Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain — Europe PMC PMID:34516550},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34516550},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_da658ea06979; sha256 e190f149d167ae54b1669b15b3b30c84414c501c73bef154ae3f5a59d7bd89a7},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34516550. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

LRRK2 gain-of-function is considered a major cause of Parkinson's disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus elicits a pleomorphic transient brain phenotype in maternal-zygotic mutant embryos (mzLrrk2). In contrast to lrrk2, the paralog gene lrrk1 is virtually not expressed in the brain of both wild-type and mzLrrk2 fish at different developmental stages. Notably, we found reduced catecholaminergic neurons, the main target of PD, in specific cell populations in the brains of mzLrrk2 larvae, but not adult fish. Strikingly, age-dependent accumulation of monoamine oxidase (MAO)-dependent catabolic signatures within mzLrrk2 brains revealed a previously undescribed interaction between LRRK2 and MAO biological activities. Our results highlight mzLrrk2 zebrafish as a tractable tool to study LRRK2 loss-of-function in vivo, and suggest a link between LRRK2 and MAO, potentially of relevance in the prodromic stages of PD.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS genetics, 2021 (prima pubblicazione 2021-09-13).
Identificativi: PMID 34516550 · PMCID PMC8459977 · DOI 10.1371/journal.pgen.1009794.
Descrittori MeSH principali: Gene Deletion.
Pagina: https://europepmc.org/article/MED/34516550 — https://doi.org/10.1371/journal.pgen.1009794. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-02T20:43:27.459Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.