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Canonic hemoglobin-oxygen equilibrium: Reassessing the role of cooperativity — arXiv:2611.00824

Source: arXiv (en)
Original: https://arxiv.org/abs/2611.00824
License (as archived): CC0-1.0
Archived: 2026-11-03T19:02:59.166Z
SHA-256 of the archived text: 0a22283517d5a7a61c7dc5639cf2eaa6efa231d214598026c05b9203e3c389dc
Stable URL of this page: https://metraipolis.com/documento/dc_da548cdbf658

How to cite

Canonic hemoglobin-oxygen equilibrium: Reassessing the role of cooperativity — arXiv:2611.00824 — arXiv (en), https://arxiv.org/abs/2611.00824 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_da548cdbf658 (Metraipolis archive dc_da548cdbf658, sha256 0a22283517d5a7a61c7dc5639cf2eaa6efa231d214598026c05b9203e3c389dc)

BibTeX

@misc{dcda548cdbf658,
  title = {Canonic hemoglobin-oxygen equilibrium: Reassessing the role of cooperativity — arXiv:2611.00824},
  howpublished = {arXiv (en)},
  url = {https://arxiv.org/abs/2611.00824},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_da548cdbf658; sha256 0a22283517d5a7a61c7dc5639cf2eaa6efa231d214598026c05b9203e3c389dc},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: arXiv (en), https://arxiv.org/abs/2611.00824. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Hemoglobin-oxygen equilibrium is normally studied within the grand canonical ensemble, which assumes that each hemoglobin is immersed in a reservoir of unbound oxygen molecules of the plasma. We show that this assumption is incorrect inside the RBC (red blood cell or erythrocyte), where the hemoglobin concentration is larger than the concentration of unbound oxygen in plasma. We suggest a better model, where a single hemoglobin and a few oxygen molecules around it reach a canonical equilibrium at a fixed volume (determined from the RBC structure) and a fixed temperature. The basic models of hemoglobin-oxygen equilibrium -- Pauling's model and Monod-Wyman-Changeux model -- can be reformulated for this canonical situation. They predict cooperative interaction energies, which are significantly lower than predictions of the same models in the grand canonical ensemble. Larger cooperative energies, in particular those predicted by the grand canonical ensemble, lead to instabilities (cascade processes) in oxygen release within the canonical approach. Oxygen-binding fluctuations within this approach are sizably smaller than those in the grand canonical situation. These results suggest that the hopping diffusion of oxygen from one hemoglobin to another may play a role in oxygen diffusion within the RBC.

Tema degli esploratori: fisica e astronomia (elenco arXiv cond-mat.stat-mech, nuovi lavori del giorno).
Categorie arXiv: Biological Physics (physics.bio-ph) ; Soft Condensed Matter (cond-mat.soft); Statistical Mechanics (cond-mat.stat-mech); Biomolecules (q-bio.BM).
Pagina del lavoro: https://arxiv.org/abs/2611.00824 — autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza: titolo e abstract sono metadati arXiv distribuiti in CC0 1.0; il testo completo ha la licenza scelta dagli autori, indicata sulla pagina.
Letto il 2026-11-03T18:20:07.782Z dalla pagina https://arxiv.org/list/cond-mat.stat-mech/new (consentita dal robots.txt di arxiv.org, con il suo crawl-delay).