Metraipolis › archive › dc_d86ced3ce46d

Long-term statin therapy is associated with severe coronary artery calcification — Europe PMC PMID:37498869

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37498869
DOI: 10.1371/journal.pone.0289111
License (as archived): CC0-1.0
Archived: 2026-10-07T12:57:35.310Z
SHA-256 of the archived text: 0f1359ce7302b5fd53634f2e0d0032b5d5bd5a5351104dfe9f9ce5355cbd4ee9
Stable URL of this page: https://metraipolis.com/documento/dc_d86ced3ce46d

How to cite

Long-term statin therapy is associated with severe coronary artery calcification — Europe PMC PMID:37498869 — Europe PMC (en), https://europepmc.org/article/MED/37498869 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_d86ced3ce46d (Metraipolis archive dc_d86ced3ce46d, sha256 0f1359ce7302b5fd53634f2e0d0032b5d5bd5a5351104dfe9f9ce5355cbd4ee9)

BibTeX

@misc{dcd86ced3ce46d,
  title = {Long-term statin therapy is associated with severe coronary artery calcification — Europe PMC PMID:37498869},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37498869},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_d86ced3ce46d; sha256 0f1359ce7302b5fd53634f2e0d0032b5d5bd5a5351104dfe9f9ce5355cbd4ee9},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37498869. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Atherosclerosis and consequent risk of cardiovascular events or mortality can be accurately assessed by quantifying coronary artery calcium score (CACS) derived from computed tomography. HMG-CoA-reductase inhibitors (statins) are the primary pharmacotherapy used to reduce cardiovascular events, yet there is growing data that support statin use may increase coronary calcification. We set out to determine the likelihood of severe CACS in the context of chronic statin therapy. Methods: We established a retrospective, case-control study of 1,181 U.S. veterans without coronary artery disease (CAD) from a single site, the Providence VA Medical Center. Duration of statin therapy for primary prevention was divided into 5-year categorical increments. The primary outcome was CACS derived from low-dose lung cancer screening computed tomography (LCSCT), stratified by CACs severity (none = 0; mild = 1-99; moderate = 100-399; and severe ≥400 AU). Statin duration of zero served as the referent control. Ordinal logistic regression analysis determined the association between duration of statin use and CACS categories. Proportional odds assumption was tested using likelihood ratio test. Atherosclerotic cardiovascular disease (ASCVD) risk score, body mass index, and CKD (glomerular filtration rate of 0-5 years, OR: 1.71 [CI: 1.34-2.18], p 5-10 years, OR: 2.80 [CI: 2.01-3.90], p 10 years, OR: 5.30 [CI: 3.23-8.70], p 0-5 years, OR: 1.49 [CI: 1.16-1.92], p = 0.002; >5-10 years, OR: 2.38 [CI: 1.7-3.35], p 10 years, OR: 4.48 [CI: 2.7-7.43], p<0.001). Conclusions: Long-term use of statins is associated with increased likelihood of severe CACS in patients with significant smoking history. The use of CACS to interpret cardiovascular event risk may require adjustment in the context of chronic statin therapy.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-07-27).
Identificativi: PMID 37498869 · PMCID PMC10374064 · DOI 10.1371/journal.pone.0289111.
Descrittori MeSH principali: Lung Neoplasms; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Atherosclerosis; Coronary Artery Disease; Vascular Calcification.
Pagina: https://europepmc.org/article/MED/37498869 — https://doi.org/10.1371/journal.pone.0289111. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T12:28:09.417Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.