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Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action — Europe PMC PMID:34919585

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34919585
DOI: 10.1371/journal.pone.0261377
License (as archived): CC0-1.0
Archived: 2026-11-01T00:38:25.647Z
SHA-256 of the archived text: 2dd1d6d466da1597adeb4f84e1b178eb25f06cf91d07563449fd681c4a753ab9
Stable URL of this page: https://metraipolis.com/documento/dc_d45dfe003d64

How to cite

Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action — Europe PMC PMID:34919585 — Europe PMC (en), https://europepmc.org/article/MED/34919585 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_d45dfe003d64 (Metraipolis archive dc_d45dfe003d64, sha256 2dd1d6d466da1597adeb4f84e1b178eb25f06cf91d07563449fd681c4a753ab9)

BibTeX

@misc{dcd45dfe003d64,
  title = {Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action — Europe PMC PMID:34919585},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34919585},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_d45dfe003d64; sha256 2dd1d6d466da1597adeb4f84e1b178eb25f06cf91d07563449fd681c4a753ab9},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34919585. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Chronic liver disease (CLD) is among the strongest risk factors for adverse prescription opioid-related events. Yet, the current prevalence and factors associated with high-risk opioid prescribing in patients with chronic liver disease (CLD) remain unclear, making it challenging to address opioid safety in this population. Therefore, we aimed to characterize opioid prescribing patterns among patients with CLD. Methods: This retrospective cohort study included patients with CLD identified at a single medical center and followed for one year from 10/1/2015-9/30/2016. Multivariable, multinomial regression was used identify the patient characteristics, including demographics, medical conditions, and liver-related factors, that were associated with opioid prescriptions and high-risk prescriptions (≥90mg morphine equivalents per day [MME/day] or co-prescribed with benzodiazepines). Results: Nearly half (47%) of 12,425 patients with CLD were prescribed opioids over a one-year period, with 17% of these receiving high-risk prescriptions. The baseline factors significantly associated with high-risk opioid prescriptions included female gender (adjusted incident rate ratio, AIRR = 1.32, 95% CI = 1.14-1.53), Medicaid insurance (AIRR = 1.68, 95% CI = 1.36-2.06), cirrhosis (AIRR = 1.22, 95% CI = 1.04-1.43) and baseline chronic pain (AIRR = 3.40, 95% CI = 2.94-4.01), depression (AIRR = 1.93, 95% CI = 1.60-2.32), anxiety (AIRR = 1.84, 95% CI = 1.53-2.22), substance use disorder (AIRR = 2.16, 95% CI = 1.67-2.79), and Charlson comorbidity score (AIRR = 1.27, 95% CI = 1.22-1.32). Non-alcoholic fatty liver disease was associated with decreased high-risk opioid prescriptions (AIRR = 0.56, 95% CI = 0.47-0.66). Conclusion: Opioid medications continue to be prescribed to nearly half of patients with CLD, despite efforts to curtail opioid prescribing due to known adverse events in this population.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-12-17).
Identificativi: PMID 34919585 · PMCID PMC8682904 · DOI 10.1371/journal.pone.0261377.
Pagina: https://europepmc.org/article/MED/34919585 — https://doi.org/10.1371/journal.pone.0261377. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-01T00:28:28.082Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.