Metraipolis › archive › dc_d36bbff65fea

Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates — Europe PMC PMID:41770779

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/41770779
DOI: 10.1371/journal.pone.0343882
License (as archived): CC0-1.0
Archived: 2026-10-06T08:19:58.577Z
SHA-256 of the archived text: 626b90be2eba81df6fdd087c49a4cb389a0db2c3d0f13d8895e1754adfddf766
Stable URL of this page: https://metraipolis.com/documento/dc_d36bbff65fea

How to cite

Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates — Europe PMC PMID:41770779 — Europe PMC (en), https://europepmc.org/article/MED/41770779 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_d36bbff65fea (Metraipolis archive dc_d36bbff65fea, sha256 626b90be2eba81df6fdd087c49a4cb389a0db2c3d0f13d8895e1754adfddf766)

BibTeX

@misc{dcd36bbff65fea,
  title = {Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates — Europe PMC PMID:41770779},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/41770779},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_d36bbff65fea; sha256 626b90be2eba81df6fdd087c49a4cb389a0db2c3d0f13d8895e1754adfddf766},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/41770779. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Salmonella enterica subspecies enterica, particularly serovar Newport, remains a leading cause of foodborne illnesses in the United States, implicated in numerous outbreaks associated with a diverse array of food products. This study systematically investigates the virulence of five distinct S. Newport isolates, characterized by varying patterns of pulse-field gel electrophoresis (PFGE) molecular-diagnostic subtyping, using the nematode Caenorhabditis elegans as a host model organism. We conducted viability assays on C. elegans to evaluate how these isolates affect nematode survival. The selected bacterial strains, chosen for their historical significance in foodborne outbreaks yet isolated form environmental sources, were previously sequenced to provide a comprehensive genomic framework. A notable focus of our research was on the nearly genetically identical PFGE types Newport-61 and the Newport-1015 isolates, which differ by a 1.7 Mb genomic inversion. C. elegans survival assays in response to pathogenic-strain infections revealed that one Newport-1015 and the Newport-61 isolates were particularly more virulent compared to other isolates tested. These findings enhance our understanding of the pathogenic potential of environmental S. Newport and highlight the need to understand the regulatory mechanisms that contribute to virulence capacity.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2026 (prima pubblicazione 2026-03-02).
Identificativi: PMID 41770779 · PMCID PMC12952584 · DOI 10.1371/journal.pone.0343882.
Descrittori MeSH principali: Caenorhabditis elegans; Salmonella enterica.
Pagina: https://europepmc.org/article/MED/41770779 — https://doi.org/10.1371/journal.pone.0343882. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T08:18:30.454Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.