Metraipolis › archive › dc_d3102eded4be

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying… — Europe PMC PMID:33002093

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33002093
DOI: 10.1371/journal.ppat.1008869
License (as archived): CC0-1.0
Archived: 2026-11-07T09:50:02.746Z
SHA-256 of the archived text: 6a4fb7ff0bff65c8c9534f8ae77e1c32cd51f90648257e4a1aae3dae0f570360
Stable URL of this page: https://metraipolis.com/documento/dc_d3102eded4be

How to cite

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying… — Europe PMC PMID:33002093 — Europe PMC (en), https://europepmc.org/article/MED/33002093 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_d3102eded4be (Metraipolis archive dc_d3102eded4be, sha256 6a4fb7ff0bff65c8c9534f8ae77e1c32cd51f90648257e4a1aae3dae0f570360)

BibTeX

@misc{dcd3102eded4be,
  title = {Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying… — Europe PMC PMID:33002093},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33002093},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_d3102eded4be; sha256 6a4fb7ff0bff65c8c9534f8ae77e1c32cd51f90648257e4a1aae3dae0f570360},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33002093. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is known regarding monocyte-derived macrophages (MDMs) that may drive atherosclerosis in this population. We isolated PBMCs from people with and without HIV, and cultured these cells for 5 days in medium containing autologous serum to generate MDMs. Differential gene expression (DGE) analysis of MDMs from PWH identified broad alterations in innate immune signaling (IL-1β, TLR expression, PPAR βδ) and lipid processing (LXR/RXR, ACPP, SREBP1). Transcriptional changes aligned with the functional capabilities of these cells. Expression of activation markers and innate immune receptors (CD163, TLR4, and CD300e) was altered on MDMs from PWH, and these cells produced more TNFα, reactive oxygen species (ROS), and matrix metalloproteinases (MMPs) than did cells from people without HIV. MDMs from PWH also had greater lipid accumulation and uptake of oxidized LDL. PWH had increased serum levels of free fatty acids (FFAs) and ceramides, with enrichment of saturated FAs and a reduction in polyunsaturated FAs. Levels of lipid classes and species that are associated with CVD correlated with unique DGE signatures and altered metabolic pathway activation in MDMs from PWH. Here, we show that MDMs from PWH display a pro-atherogenic phenotype; they readily form foam cells, have altered transcriptional profiles, and produce mediators that likely contribute to accelerated ASCVD.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2020 (prima pubblicazione 2020-10-01).
Identificativi: PMID 33002093 · PMCID PMC7553323 · DOI 10.1371/journal.ppat.1008869.
Descrittori MeSH principali: Models, Cardiovascular.
Pagina: https://europepmc.org/article/MED/33002093 — https://doi.org/10.1371/journal.ppat.1008869. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T09:43:56.369Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.