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A study protocol for determining the role of Sympathetic activity in Post-injury outcomes: Impact on sleep and caRdiovascular health InvesTigation (SPIRIT) — Europe PMC PMID:40674309

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40674309
DOI: 10.1371/journal.pone.0321035
License (as archived): CC0-1.0
Archived: 2026-10-06T09:45:07.127Z
SHA-256 of the archived text: bfbf66f8c02361490d034e49de4b59cf11d769a6159cc4e37adcafc4eca1ba62
Stable URL of this page: https://metraipolis.com/documento/dc_d14bd97aed90

How to cite

A study protocol for determining the role of Sympathetic activity in Post-injury outcomes: Impact on sleep and caRdiovascular health InvesTigation (SPIRIT) — Europe PMC PMID:40674309 — Europe PMC (en), https://europepmc.org/article/MED/40674309 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_d14bd97aed90 (Metraipolis archive dc_d14bd97aed90, sha256 bfbf66f8c02361490d034e49de4b59cf11d769a6159cc4e37adcafc4eca1ba62)

BibTeX

@misc{dcd14bd97aed90,
  title = {A study protocol for determining the role of Sympathetic activity in Post-injury outcomes: Impact on sleep and caRdiovascular health InvesTigation (SPIRIT) — Europe PMC PMID:40674309},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40674309},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_d14bd97aed90; sha256 bfbf66f8c02361490d034e49de4b59cf11d769a6159cc4e37adcafc4eca1ba62},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40674309. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Introduction: A growing body of research indicates that combat-injured service members are at heightened risk of a wide range of adverse physical and mental health outcomes. However, data on long-term health outcomes of United States (US) combat-injured service members remain limited, particularly in relation to cardiovascular outcomes and potential underlying mechanisms. The goal of the "determining the role of sympathetic activity in post-injury outcomes: impact on sleep and cardiovascular health investigation (SPIRIT)" study is to better understand the relationship between combat injury severity and cardiovascular function, sleep disorders, and mental health concerns among post-9/11 US combat casualties. Methods: Here, we describe a remotely conducted, nationwide, cross-sectional study of 100 minimally injured (Injury Severity Score [ISS] ≤ 3) and 100 severely injured (ISS ≥ 14) post-9/11 US combat casualties. Injury and demographic data will be collected from both retrospective sources and the participants themselves. Participants will complete well-validated surveys electronically to assess mental health symptoms and sleep problems. Three wearable devices will be mailed to participants: (1) an ambulatory electrocardiogram (ECG) monitor for seven days of wear, (2) a Home Sleep Test (HST) device to be worn for one night, and (3) a 24-hour ambulatory blood pressure monitor to be worn for one day. Lastly, participants will visit a local laboratory to provide blood and urine samples for analysis. This protocol is registered on Clinicaltrials.gov under #NCT05971433. Results and conclusions: This study will be among the first to remotely evaluate long-term physical and mental health outcomes in US combat casualties. This study aims to collect robust at-home ECG, sleep, and blood pressure data and examine the associations of combat injury severity with sleep disorders, mental health, cardiovascular risk, and sympathetic nervous system activation. Findings will help inform future research, such as interventional or subsequent longitudinal observational investigations of combat-injured veterans.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-07-17).
Identificativi: PMID 40674309 · PMCID PMC12270146 · DOI 10.1371/journal.pone.0321035.
Descrittori MeSH principali: Sympathetic Nervous System; Wounds and Injuries; Sleep; Sleep Wake Disorders.
Pagina: https://europepmc.org/article/MED/40674309 — https://doi.org/10.1371/journal.pone.0321035. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T09:43:20.341Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.