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An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections — Europe PMC PMID:32804954

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32804954
DOI: 10.1371/journal.pntd.0008381
License (as archived): CC0-1.0
Archived: 2026-11-07T18:12:26.647Z
SHA-256 of the archived text: a88606555e1c7fdead609524d7f5f00368257c1eac3136179d78f49e1ae67144
Stable URL of this page: https://metraipolis.com/documento/dc_cf7cd4c0c745

How to cite

An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections — Europe PMC PMID:32804954 — Europe PMC (en), https://europepmc.org/article/MED/32804954 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_cf7cd4c0c745 (Metraipolis archive dc_cf7cd4c0c745, sha256 a88606555e1c7fdead609524d7f5f00368257c1eac3136179d78f49e1ae67144)

BibTeX

@misc{dccf7cd4c0c745,
  title = {An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections — Europe PMC PMID:32804954},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32804954},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_cf7cd4c0c745; sha256 a88606555e1c7fdead609524d7f5f00368257c1eac3136179d78f49e1ae67144},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32804954. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The world's most consequential pathogens occur in regions with the fewest diagnostic resources, leaving the true burden of these diseases largely under-represented. During a prospective observational study of sepsis in Takeo Province Cambodia, we enrolled 200 patients over an 18-month period. By coupling traditional diagnostic methods such as culture, serology, and PCR to Next Generation Sequencing (NGS) and advanced statistical analyses, we successfully identified a pathogenic cause in 46.5% of our cohort. In all, we detected 25 infectious agents in 93 patients, including severe threat pathogens such as Burkholderia pseudomallei and viral pathogens such as Dengue virus. Approximately half of our cohort remained undiagnosed; however, an independent panel of clinical adjudicators determined that 81% of those patients had infectious causes of their hospitalization, further underscoring the difficulty of diagnosing severe infections in resource-limited settings. We garnered greater insight as to the clinical features of severe infection in Cambodia through analysis of a robust set of clinical data.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS neglected tropical diseases, 2020 (prima pubblicazione 2020-08-17).
Identificativi: PMID 32804954 · PMCID PMC7430706 · DOI 10.1371/journal.pntd.0008381.
Pagina: https://europepmc.org/article/MED/32804954 — https://doi.org/10.1371/journal.pntd.0008381. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T18:08:12.836Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.