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Birth cohort relative to an influenza A virus's antigenic cluster introduction drives patterns of children's antibody titers — Europe PMC PMID:35192673

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35192673
DOI: 10.1371/journal.ppat.1010317
License (as archived): CC0-1.0
Archived: 2026-10-31T09:13:40.044Z
SHA-256 of the archived text: bd1d8473fc2c123220bd97671cb95cb84ae5e5e9b2fed638a54b35f650c8d4dc
Stable URL of this page: https://metraipolis.com/documento/dc_cf72a0aaa50d

How to cite

Birth cohort relative to an influenza A virus's antigenic cluster introduction drives patterns of children's antibody titers — Europe PMC PMID:35192673 — Europe PMC (en), https://europepmc.org/article/MED/35192673 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_cf72a0aaa50d (Metraipolis archive dc_cf72a0aaa50d, sha256 bd1d8473fc2c123220bd97671cb95cb84ae5e5e9b2fed638a54b35f650c8d4dc)

BibTeX

@misc{dccf72a0aaa50d,
  title = {Birth cohort relative to an influenza A virus's antigenic cluster introduction drives patterns of children's antibody titers — Europe PMC PMID:35192673},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35192673},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_cf72a0aaa50d; sha256 bd1d8473fc2c123220bd97671cb95cb84ae5e5e9b2fed638a54b35f650c8d4dc},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35192673. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

An individual's antibody titers to influenza A strains are a result of the complicated interplay between infection history, cross-reactivity, immune waning, and other factors. It has been challenging to disentangle how population-level patterns of humoral immunity change as a function of age, calendar year, and birth cohort from cross-sectional data alone. We analyzed 1,589 longitudinal sera samples from 260 children across three studies in Nicaragua, 2006-16. Hemagglutination inhibition (HAI) titers were determined against four H3N2 strains, one H1N1 strain, and two H1N1pdm strains. We assessed temporal patterns of HAI titers using an age-period-cohort modeling framework. We found that titers against a given virus depended on calendar year of serum collection and birth cohort but not on age. Titer cohort patterns were better described by participants' ages relative to year of likely introduction of the virus's antigenic cluster than by age relative to year of strain introduction or by year of birth. These cohort effects may be driven by a decreasing likelihood of early-life infection after cluster introduction and by more broadly reactive antibodies at a young age. H3N2 and H1N1 viruses had qualitatively distinct cohort patterns, with cohort patterns of titers to specific H3N2 strains reaching their peak in children born 3 years prior to that virus's antigenic cluster introduction and with titers to H1N1 and H1N1pdm strains peaking for children born 1-2 years prior to cluster introduction but not being dramatically lower for older children. Ultimately, specific patterns of strain circulation and antigenic cluster introduction may drive population-level antibody titer patterns in children.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2022 (prima pubblicazione 2022-02-22).
Identificativi: PMID 35192673 · PMCID PMC8896668 · DOI 10.1371/journal.ppat.1010317.
Descrittori MeSH principali: Influenza Vaccines; Influenza, Human; Influenza A Virus, H1N1 Subtype.
Pagina: https://europepmc.org/article/MED/35192673 — https://doi.org/10.1371/journal.ppat.1010317. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-31T09:01:45.955Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.