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Anti-inflammatory activity of diindolylmethane alleviates Riemerella anatipestifer infection in ducks — Europe PMC PMID:33175869

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33175869
DOI: 10.1371/journal.pone.0242198
License (as archived): CC0-1.0
Archived: 2026-11-06T23:26:26.942Z
SHA-256 of the archived text: d6b91547ddb96526d2d467e07a6da1cdd83754e6a08e6b9f15e64bc1e589b53f
Stable URL of this page: https://metraipolis.com/documento/dc_cf127701ac65

How to cite

Anti-inflammatory activity of diindolylmethane alleviates Riemerella anatipestifer infection in ducks — Europe PMC PMID:33175869 — Europe PMC (en), https://europepmc.org/article/MED/33175869 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_cf127701ac65 (Metraipolis archive dc_cf127701ac65, sha256 d6b91547ddb96526d2d467e07a6da1cdd83754e6a08e6b9f15e64bc1e589b53f)

BibTeX

@misc{dccf127701ac65,
  title = {Anti-inflammatory activity of diindolylmethane alleviates Riemerella anatipestifer infection in ducks — Europe PMC PMID:33175869},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33175869},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_cf127701ac65; sha256 d6b91547ddb96526d2d467e07a6da1cdd83754e6a08e6b9f15e64bc1e589b53f},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33175869. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

3,3'-Diindolylmethane (DIM) is found in cruciferous vegetables and is used to treat various inflammatory diseases because of its potential anti-inflammatory effects. To investigate effects of DIM in Riemerella anatipestifer-infected ducks which induce upregulation of inflammatory cytokines, ducks were treated orally with DIM at dose of 200 mg/kg/day and infected the following day with R. anatipestifer. Infected and DIM-treated ducks exhibited 14% increased survival rate and significantly decreased bacterial burden compared to infected untreated ducks. Next, the effect on the expression level of inflammatory cytokines (interleukin [IL]-17A, IL-17F, IL-6, IL-1β) of both in vitro and in vivo DIM-treated groups was monitored by quantitative reverse-transcription PCR (qRT-PCR). Generally, the expression levels of the cytokines were significantly reduced in DIM-treated splenic lymphocytes stimulated with killed R. anatipestifer compared to stimulated untreated splenic lymphocytes. Similarly, the expression levels of the cytokines were significantly reduced in the spleens and livers of DIM-treated R. anatipestifer-infected ducks compared to infected untreated ducks. This study demonstrated the ameliorative effects of DIM in ducks infected with R. anatipestifer. Thus, DIM can potentially be used to prevent and/or treat R. anatipestifer infection via inhibition of inflammatory cytokine expression.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2020 (prima pubblicazione 2020-11-11).
Identificativi: PMID 33175869 · PMCID PMC7657562 · DOI 10.1371/journal.pone.0242198.
Pagina: https://europepmc.org/article/MED/33175869 — https://doi.org/10.1371/journal.pone.0242198. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-06T23:23:22.769Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.