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Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions — Europe PMC PMID:40051047

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40051047
DOI: 10.1080/15476286.2025.2475421
License (as archived): CC0-1.0
Archived: 2026-10-06T12:00:57.182Z
SHA-256 of the archived text: 453dcd67261f8fb8fa30b0c15905618580fb099639f5b61960f6609b385057a9
Stable URL of this page: https://metraipolis.com/documento/dc_ce09ff893e5e

How to cite

Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions — Europe PMC PMID:40051047 — Europe PMC (en), https://europepmc.org/article/MED/40051047 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ce09ff893e5e (Metraipolis archive dc_ce09ff893e5e, sha256 453dcd67261f8fb8fa30b0c15905618580fb099639f5b61960f6609b385057a9)

BibTeX

@misc{dcce09ff893e5e,
  title = {Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions — Europe PMC PMID:40051047},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40051047},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ce09ff893e5e; sha256 453dcd67261f8fb8fa30b0c15905618580fb099639f5b61960f6609b385057a9},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40051047. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Super enhancers are important regulators of gene expression that often overlap with protein-coding genes. However, it is unclear whether the overlapping protein-coding genes and the RNA derived from them contribute to enhancer activity. Using an erythroid-specific super enhancer that overlaps the Cpox gene as a model, Cpox pre-mRNA is found to have a non-coding function in regulating neighbouring protein-coding genes, eRNA expression and TAD interactions. Depletion of Cpox pre-mRNA leads to accumulation of H3K27me3 and release of p300 from the Cpox locus, activating an intra-TAD enhancer and gene expression. Additionally, a head-to-tail interaction between the TAD boundary genes Cpox and Dcbld2 is identified, facilitated by a novel type of repressive loop anchored by p300 and PRC2/H3K27me3. These results uncover a regulatory role for pre-mRNA transcribed within a super enhancer context and provide insight into head-to-tail inter-gene interaction in the regulation of gene expression and oncogene activation.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: RNA biology, 2025 (prima pubblicazione 2025-03-12).
Identificativi: PMID 40051047 · PMCID PMC11913378 · DOI 10.1080/15476286.2025.2475421.
Parole chiave degli autori: Oncogene; Gene silencing; Chromatin Structure; Chromatin Regulation; Super Enhancer; Tad Boundary; Inter-gene Interaction.
Descrittori MeSH principali: Chromatin; RNA Precursors; Gene Expression Regulation; Enhancer Elements, Genetic.
Pagina: https://europepmc.org/article/MED/40051047 — https://doi.org/10.1080/15476286.2025.2475421. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T10:21:18.047Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.