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Amisulpride — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Amisulpride
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-08T22:36:34.723Z
SHA-256 of the archived text: 8065b1d93fafb9d902a7f0eff8b75daa28931968a6d27bc4908284716d58e8b1
Stable URL of this page: https://metraipolis.com/documento/dc_cde54eff25db

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Amisulpride — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Amisulpride (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_cde54eff25db (Metraipolis archive dc_cde54eff25db, sha256 8065b1d93fafb9d902a7f0eff8b75daa28931968a6d27bc4908284716d58e8b1)

BibTeX

@misc{dccde54eff25db,
  title = {Amisulpride — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Amisulpride},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_cde54eff25db; sha256 8065b1d93fafb9d902a7f0eff8b75daa28931968a6d27bc4908284716d58e8b1},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Amisulpride. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Amisulpride, sold under the brand names Socian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting, at low doses by mouth to treat depression, and at higher doses by mouth to treat psychosis. It is usually classed with the atypical antipsychotics. Chemically it is a benzamide and like other benzamide antipsychotics, such as sulpiride, it is associated with a high risk of elevating blood levels of the lactation hormone, prolactin (thereby potentially causing the absence of the menstrual cycle, breast enlargement, even in males, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc.), and a low risk, relative to the typical antipsychotics, of causing movement disorders. Amisulpride is indicated for use in the United States in adults for the prevention of postoperative nausea and vomiting (PONV), either alone or in combination with an antiemetic of a different class; and to treat PONV in those who have received antiemetic prophylaxis with an agent of a different class or have not received prophylaxis. Amisulpride is believed to work by blocking, or antagonizing, the dopamine D2 receptor, reducing its signalling. The effectiveness of amisulpride in treating dysthymia and the negative symptoms of schizophrenia is believed to stem from its blockade of the presynaptic dopamine D2 and D3 autoreceptors. These presynaptic receptors regulate the release of dopamine into the synapse, so by blocking them amisulpride increases dopamine concentrations in the synapse. This increased dopamine concentration is theorized to act on dopamine D1 receptors to relieve depressive symptoms (in dysthymia) and the negative symptoms of schizophrenia. It was introduced by Sanofi-Aventis in the 1990s. Its patent expired by 2008, and generic formulations became available. It is marketed in all English-speaking countries except for Canada.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Amisulpride» — https://en.wikipedia.org/wiki/Amisulpride
Wikidata Q418785: «group of stereoisomers» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q418785
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Amisulpride?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1384444382, consultata il 2026-11-08T22:32:50.077Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 8fad577558e3d65d4a913d88be0b97523e695e0472ea625b6a4fb71c453ad8fe