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Cryptic self epitopes — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Cryptic_self_epitopes
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T12:31:36.897Z
SHA-256 of the archived text: 59c5aec18eb5d188c7724d6ed58d12864a4cf0a43f8a413974cdc1df515136d7
Stable URL of this page: https://metraipolis.com/documento/dc_cd8fcf17addf

How to cite

Cryptic self epitopes — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Cryptic_self_epitopes (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_cd8fcf17addf (Metraipolis archive dc_cd8fcf17addf, sha256 59c5aec18eb5d188c7724d6ed58d12864a4cf0a43f8a413974cdc1df515136d7)

BibTeX

@misc{dccd8fcf17addf,
  title = {Cryptic self epitopes — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Cryptic_self_epitopes},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_cd8fcf17addf; sha256 59c5aec18eb5d188c7724d6ed58d12864a4cf0a43f8a413974cdc1df515136d7},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Cryptic_self_epitopes. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

In immunology, cryptic self epitopes are a source of autoimmunity. Self epitopes, which are found in high concentration on the surface of antigen-presenting cells (APCs) in association with its major histocompatibility complex (MHC) are known as dominant epitopes. These are stimulants of negative selection mechanisms to remove potentially self destructing autoreactive T cells. Their "self" antigens are displayed to a developing T-cell and signal those "self-reactive" T-cells to die via programmed cell death (apoptosis) and thereby deletion from the T cell repertoire, preventing autoimmunity. However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete autoreactive T-cells which will then join the peripheral adult T cell repertoire. This causes autoimmunity in the body.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Immunology»).
Fonte: Wikipedia in inglese, voce «Cryptic self epitopes» — https://en.wikipedia.org/wiki/Cryptic_self_epitopes
Wikidata Q5190774 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q5190774
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Cryptic_self_epitopes?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1163075932, consultata il 2026-10-07T12:03:58.051Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: c6291e4ab3681e3f53eef61aa9f9c8556dd759514ba3f62c532d8345dcf6207a