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Sulfur dioxide exposure of mice induces peribronchiolar fibrosis-A defining feature of deployment-related constrictive bronchiolitis — Europe PMC PMID:39854594

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/39854594
DOI: 10.1371/journal.pone.0313992
License (as archived): CC0-1.0
Archived: 2026-10-06T13:46:05.758Z
SHA-256 of the archived text: 95bf45ae5b5b54328758cb884b23db764dae664b501bc98dbbb415d6e0fb1fa0
Stable URL of this page: https://metraipolis.com/documento/dc_ccb201a152ba

How to cite

Sulfur dioxide exposure of mice induces peribronchiolar fibrosis-A defining feature of deployment-related constrictive bronchiolitis — Europe PMC PMID:39854594 — Europe PMC (en), https://europepmc.org/article/MED/39854594 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ccb201a152ba (Metraipolis archive dc_ccb201a152ba, sha256 95bf45ae5b5b54328758cb884b23db764dae664b501bc98dbbb415d6e0fb1fa0)

BibTeX

@misc{dcccb201a152ba,
  title = {Sulfur dioxide exposure of mice induces peribronchiolar fibrosis-A defining feature of deployment-related constrictive bronchiolitis — Europe PMC PMID:39854594},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/39854594},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ccb201a152ba; sha256 95bf45ae5b5b54328758cb884b23db764dae664b501bc98dbbb415d6e0fb1fa0},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/39854594. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Deployment-related constrictive bronchiolitis (DRCB) has emerged as a health concern in military personnel returning from Southwest Asia. Exposure to smoke from a fire at the Al-Mishraq sulfur enrichment facility and/or burn pits was reported by a subset of Veterans diagnosed with this disorder. DRCB is characterized by thickening and fibrosis of small airways (SA) in the lung, but whether these are related to toxin inhalation remains uncertain. The aim of this study was to determine whether sulfur dioxide (SO2) exposure can induce histopathological features of DRCB. C57BL/6J mice were exposed to 50 ± 5 ppm SO2 for one hour/day for five consecutive days. Lungs from exposed and unexposed mice were evaluated on day 5, 10, and 20. Lung sections were stained using hematoxylin and eosin, Masson's trichrome, picrosirius red (PSR), and immunofluorescence for club cell secretory protein, acetylated-α-tubulin, and Ki67. Small airway wall thickness was determined by morphometric analysis and collagen content was quantified by measuring PSR fluorescence intensity. CurveAlign and CT-FIRE were used to enumerate collagen fibers and assess fibers' width and length, respectively. Leukocyte subpopulations were quantified by flow cytometry analysis. This protocol of SO2 exposure of mice: 1) Triggered club cell proliferation and differentiation; 2) Increased SA wall thickness by inducing subepithelial collagen deposition; and 3) Increased width, length, and number, but not density, of collagen fibers within the wall of SA. 4) Induced no peribronchiolar inflammation or respiratory bronchiolitis. Collectively, these findings implicate club cell proliferation and differentiation in the profibrotic response to SO2 and identify this SO2 exposure as a potentially effective though imperfect model for studying SA fibrosis in DRCB.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-01-24).
Identificativi: PMID 39854594 · PMCID PMC11761160 · DOI 10.1371/journal.pone.0313992.
Descrittori MeSH principali: Bronchiolitis Obliterans; Sulfur Dioxide.
Pagina: https://europepmc.org/article/MED/39854594 — https://doi.org/10.1371/journal.pone.0313992. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T12:00:49.474Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.