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Resistance exercise protects mice from protein-induced fat accretion — Europe PMC PMID:38019262

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38019262
DOI: 10.7554/elife.91007
License (as archived): CC0-1.0
Archived: 2026-10-07T11:58:57.058Z
SHA-256 of the archived text: 9fd01bdc94b23e716dccfc5abe2050e18c3937d6f4f61b06924a8a735669ed66
Stable URL of this page: https://metraipolis.com/documento/dc_cb768ea7cbed

How to cite

Resistance exercise protects mice from protein-induced fat accretion — Europe PMC PMID:38019262 — Europe PMC (en), https://europepmc.org/article/MED/38019262 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_cb768ea7cbed (Metraipolis archive dc_cb768ea7cbed, sha256 9fd01bdc94b23e716dccfc5abe2050e18c3937d6f4f61b06924a8a735669ed66)

BibTeX

@misc{dccb768ea7cbed,
  title = {Resistance exercise protects mice from protein-induced fat accretion — Europe PMC PMID:38019262},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38019262},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_cb768ea7cbed; sha256 9fd01bdc94b23e716dccfc5abe2050e18c3937d6f4f61b06924a8a735669ed66},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38019262. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Low-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we examine this paradox using weight pulling, a validated progressive resistance exercise training regimen, in mice fed either an LP diet or an isocaloric HP diet. We find that despite having lower food consumption than the LP group, HP-fed mice gain significantly more fat mass than LP-fed mice when not exercising, while weight pulling protected HP-fed mice from this excess fat accretion. The HP diet augmented exercise-induced hypertrophy of the forearm flexor complex, and weight pulling ability increased more rapidly in the exercised HP-fed mice. Surprisingly, exercise did not protect from HP-induced changes in glycemic control. Our results confirm that HP diets can augment muscle hypertrophy and accelerate strength gain induced by resistance exercise without negative effects on fat mass, and also demonstrate that LP diets may be advantageous in the sedentary. Our results highlight the need to consider both dietary composition and activity, not simply calories, when taking a precision nutrition approach to health.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2023 (prima pubblicazione 2023-11-29).
Identificativi: PMID 38019262 · PMCID PMC10686620 · DOI 10.7554/elife.91007.
Parole chiave degli autori: Mouse; Dietary protein; Medicine; Body composition; Resistance Training; Metabolic Health.
Descrittori MeSH principali: Resistance Training; Diet, High-Protein.
Pagina: https://europepmc.org/article/MED/38019262 — https://doi.org/10.7554/elife.91007. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T11:29:04.329Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.