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Integrating Selection and Risk Assessment of Chemical Mixtures: A Novel Approach Applied to a Breast Milk Survey — Europe PMC PMID:35238606

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/35238606
DOI: 10.1289/ehp8262
License (as archived): CC0-1.0
Archived: 2026-10-31T08:33:19.383Z
SHA-256 of the archived text: 4d2576c6d2a029d9f7d3b77b2a67368702a4b132aefb48b1f63ebc556d439996
Stable URL of this page: https://metraipolis.com/documento/dc_caaec445e876

How to cite

Integrating Selection and Risk Assessment of Chemical Mixtures: A Novel Approach Applied to a Breast Milk Survey — Europe PMC PMID:35238606 — Europe PMC (en), https://europepmc.org/article/MED/35238606 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_caaec445e876 (Metraipolis archive dc_caaec445e876, sha256 4d2576c6d2a029d9f7d3b77b2a67368702a4b132aefb48b1f63ebc556d439996)

BibTeX

@misc{dccaaec445e876,
  title = {Integrating Selection and Risk Assessment of Chemical Mixtures: A Novel Approach Applied to a Breast Milk Survey — Europe PMC PMID:35238606},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/35238606},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_caaec445e876; sha256 4d2576c6d2a029d9f7d3b77b2a67368702a4b132aefb48b1f63ebc556d439996},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/35238606. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: One of the main challenges of modern risk assessment is to account for combined exposure to the multitude of various substances present in food and the environment. Objective: The present work proposes a methodological approach to perform chemical risk assessment of contaminant mixtures across regulatory silos regarding an extensive range of substances and to do so when comprehensive relevant data concerning the specific effects and modes of action of the mixture components are not available. Methods: We developed a complete step-by-step approach using statistical methods to prioritize substances involved in combined exposure, and we used a component-based approach to cumulate the risk using dose additivity. The most relevant toxicological end point and the associated reference point were selected from the literature to construct a toxicological threshold for each substance. Discussion: By applying the proposed method to contaminants in breast milk, we observed that among the 19 substances comprising the selected mixture, ∑DDT, ∑PCBi, and arsenic were main joint contributors to the risk of neurodevelopmental and thyroid effects for infants. In addition, ∑PCCD/F contributed to the thyroid effect and ∑aldrin-dieldrin to the neurodevelopmental effect. Our case study on contaminants in breast milk demonstrated the importance of crossing regulatory silos when studying mixtures and the importance of identifying risk drivers to regulate the risk related to environmental contamination. Applying this method to another set of data, such as human biomonitoring or in ecotoxicology, will reinforce its relevance for risk assessment. https://doi.org/10.1289/EHP8262.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2022 (prima pubblicazione 2022-03-03).
Identificativi: PMID 35238606 · PMCID PMC8893236 · DOI 10.1289/ehp8262.
Descrittori MeSH principali: Milk, Human.
Pagina: https://europepmc.org/article/MED/35238606 — https://doi.org/10.1289/ehp8262. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-31T08:23:32.440Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.