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8β-VE2 — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/8%CE%B2-VE2
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-06T21:41:28.566Z
SHA-256 of the archived text: b9a0deeffec0653853204f384a335954c14c450a76a5f53659a3cb47d6e806df
Stable URL of this page: https://metraipolis.com/documento/dc_ca462bc3ed91

How to cite

8β-VE2 — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/8%CE%B2-VE2 (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_ca462bc3ed91 (Metraipolis archive dc_ca462bc3ed91, sha256 b9a0deeffec0653853204f384a335954c14c450a76a5f53659a3cb47d6e806df)

BibTeX

@misc{dcca462bc3ed91,
  title = {8β-VE2 — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/8%CE%B2-VE2},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_ca462bc3ed91; sha256 b9a0deeffec0653853204f384a335954c14c450a76a5f53659a3cb47d6e806df},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/8%CE%B2-VE2. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

8β-VE2, or 8β-vinylestradiol, also known as 8β-vinylestra-1,3,5(10)-triene-3β,17β-diol, is a synthetic estrogen featuring an estradiol core. It is a highly potent and selective agonist of the ERβ that is used in scientific research to study the function of the ERβ. It has 190-fold higher potency in transactivation assays of the ERβ relative to the ERα and 93- (rat) and 180-fold (human) preference in binding affinity for the ERβ over the ERα. In rodents, 8β-VE2 stimulates follicular growth and to a comparable extent as estradiol, whereas the highly ERα-selective agonist 16α-LE2 has no effect on ovarian follicle development, indicating that the ERβ and not the ERα is involved in the effects of estrogen on ovarian follicles. In contrast, 16α-LE2 stimulates uterine weight, whereas 8β-VE2 has no effect, indicating that the ERα and not the ERβ is involved in the effects of estrogen on the uterus. Research has determined through experimental rodent studies with estradiol, 16α-LE2, and 8β-VE2 that the positive, protective effects of estrogens on bone formation resorption and bone mineral density are mediated via the ERα, whereas the ERβ does not appear to be involved. On the other hand, while both ERα and ERβ are expressed in skeletal muscle, it was found that ERβ is the predominant ER subtype that is responsible for estrogen stimulation of skeletal muscle growth and regeneration. Moreover, similarly to testosterone, 8β-VE2 has anabolic effects in skeletal muscle and significantly increases muscle mass as well as produces muscle hypertrophy in rats. In contrast to testosterone however, 8β-VE2 shows no androgenic effects. The effects of 8β-VE2 and ERβ may be mediated, in part, by local stimulation of insulin-like growth factor 1 (IGF-1)-induced myogenic protein synthesis, as 8β-VE2 has been found to strongly induce expression of IGF-1 in the rat levator ani muscle.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «8β-VE2» — https://en.wikipedia.org/wiki/8%CE%B2-VE2
Wikidata Q28209299: «composto chimico» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q28209299
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/8%CE%B2-VE2?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1329023812, consultata il 2026-11-06T21:38:16.193Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 731500a6fd3d7177eff134846039bcaa2adc9bf8b3617d06ef9f3bc619e0ee4d