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ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence — Europe PMC PMID:36603017

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/36603017
DOI: 10.1371/journal.ppat.1011003
License (as archived): CC0-1.0
Archived: 2026-10-08T01:46:23.886Z
SHA-256 of the archived text: 6d154d829999d9be2178001d0cd80967ec250ee8721e6bdf73dd7f48ef721b78
Stable URL of this page: https://metraipolis.com/documento/dc_ca2bf2e54575

How to cite

ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence — Europe PMC PMID:36603017 — Europe PMC (en), https://europepmc.org/article/MED/36603017 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_ca2bf2e54575 (Metraipolis archive dc_ca2bf2e54575, sha256 6d154d829999d9be2178001d0cd80967ec250ee8721e6bdf73dd7f48ef721b78)

BibTeX

@misc{dcca2bf2e54575,
  title = {ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence — Europe PMC PMID:36603017},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/36603017},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_ca2bf2e54575; sha256 6d154d829999d9be2178001d0cd80967ec250ee8721e6bdf73dd7f48ef721b78},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/36603017. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Toxoplasma gondii (T. gondii) is a zoonotic apicomplexan parasite that is an important cause of clinical disability in humans. On a global scale, one third of the human population is infected with T. gondii. Mice and other small rodents are believed to be responsible for transmission of T. gondii to the domestic cat, its definitive host. Interferon-inducible Immunity-Related GTPases (IRG proteins) are important for control of murine T. gondii infections. Virulence differences between T. gondii strains are linked to polymorphic rhoptry proteins (ROPs) that cooperate to inactivate individual IRG family members. In particular, the pseudokinase ROP5 isoform B is critically important in laboratory strains of mice. We identified T. gondii ROP39 in complex with ROP5B and demonstrate its contribution to acute T. gondii virulence. ROP39 directly targets Irgb10 and inhibits homodimer formation of the GTPase leading to an overall reduction of IRG protein loading onto the parasitophorous vacuolar membrane (PVM). Maintenance of PVM integrity rescues the parasite from IRG protein-mediated clearance in vitro and in vivo. This study identifies a novel T. gondii effector that is important for specific inactivation of the IRG resistance system. Our data reveal that yet unknown T. gondii effectors can emerge from identification of direct interaction partners of ROP5B.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2023 (prima pubblicazione 2023-01-05).
Identificativi: PMID 36603017 · PMCID PMC9848475 · DOI 10.1371/journal.ppat.1011003.
Descrittori MeSH principali: Parasites; Toxoplasma; Toxoplasmosis.
Pagina: https://europepmc.org/article/MED/36603017 — https://doi.org/10.1371/journal.ppat.1011003. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T01:22:35.972Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.