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The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective — Europe PMC PMID:41247781

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/41247781
DOI: 10.7554/elife.106308
License (as archived): CC0-1.0
Archived: 2026-10-06T08:50:24.277Z
SHA-256 of the archived text: 8e94a6185521370b69df12b1ef524e3675b18199aeee58ce7ce95c1166a00511
Stable URL of this page: https://metraipolis.com/documento/dc_c19ed49c2db3

How to cite

The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective — Europe PMC PMID:41247781 — Europe PMC (en), https://europepmc.org/article/MED/41247781 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_c19ed49c2db3 (Metraipolis archive dc_c19ed49c2db3, sha256 8e94a6185521370b69df12b1ef524e3675b18199aeee58ce7ce95c1166a00511)

BibTeX

@misc{dcc19ed49c2db3,
  title = {The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective — Europe PMC PMID:41247781},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/41247781},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_c19ed49c2db3; sha256 8e94a6185521370b69df12b1ef524e3675b18199aeee58ce7ce95c1166a00511},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/41247781. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

A major health challenge resulting from the COVID-19 pandemic is the manifestation of post-acute sequelae of SARS-CoV-2 (PASC). PASC (or long COVID) is a collective term used for clinical symptoms, various pathologies, and life-quality-changing functional impairment that persist for months to years after the initial SARS-CoV-2 infection. The mechanisms underlying PASC are not understood, although advances have been made in identifying factors that may contribute to long-term pathology. Recent data have emerged, showing an association between SARS-CoV-2 viral persistence and non-SARS-CoV-2 infections (pre-existing, viral reactivation, or new infections) in facilitating or mediating PASC. However, the heterogeneous nature and timing of co-infections have made it challenging to understand, interpret, and contextualize their contribution to PASC. Here, we summarize the impact of potential viral, bacterial, and fungal infections on SARS-CoV-2 pathogenesis, with a focus on their possible roles in the development of PASC. We also provide a framework to understand the mechanisms of PASC and inform basic, translational, and clinical research initiatives, including RECOVER, a large and ongoing research initiative to understand, treat, and prevent long COVID.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2025 (prima pubblicazione 2025-11-17).
Identificativi: PMID 41247781 · PMCID PMC12622966 · DOI 10.7554/elife.106308.
Parole chiave degli autori: Microbiology; Infectious disease; Inflammation; immunology; Co-infection; Pasc; Sars-cov-2; Long Covid.
Descrittori MeSH principali: Coinfection; COVID-19; SARS-CoV-2.
Pagina: https://europepmc.org/article/MED/41247781 — https://doi.org/10.7554/elife.106308. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T08:20:26.624Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.