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XX male syndrome — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/XX_male_syndrome
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-08T00:10:18.507Z
SHA-256 of the archived text: 61c9270d4ada565a0e77097fbcb3dcdac6c099ac77005b331c414fc2e5b7e2cb
Stable URL of this page: https://metraipolis.com/documento/dc_c19e6addcd64

How to cite

XX male syndrome — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/XX_male_syndrome (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_c19e6addcd64 (Metraipolis archive dc_c19e6addcd64, sha256 61c9270d4ada565a0e77097fbcb3dcdac6c099ac77005b331c414fc2e5b7e2cb)

BibTeX

@misc{dcc19e6addcd64,
  title = {XX male syndrome — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/XX_male_syndrome},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_c19e6addcd64; sha256 61c9270d4ada565a0e77097fbcb3dcdac6c099ac77005b331c414fc2e5b7e2cb},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/XX_male_syndrome. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

XX male syndrome, also known as de la Chapelle syndrome or 46,XX testicular disorder of sex development (or 46,XX DSD) is a rare condition in which an individual with a 46,XX karyotype develops a male phenotype. In 90 percent of these individuals, the syndrome is caused by the father's Y chromosome's SRY gene being atypically included in the crossing over of genetic information that takes place between the pseudoautosomal regions of the X and Y chromosomes during meiosis in the father. When the X with the SRY gene combines with a normal X from the mother during fertilization, the result is an XX genetic male. Less common are SRY-negative individuals, who appear to be XX genetic females, which is caused by a mutation in an autosomal or X chromosomal gene. Masculinization in those with the condition is variable, and those with the condition are sterile. This syndrome is diagnosed and occurs in approximately 1 in 20,000 newborn boys, making it much less common than Klinefelter syndrome. Medical treatment of the condition varies, with medical treatment usually not necessary. The clinical name "de la Chapelle syndrome", was named after the Finnish scientist Albert de la Chapelle, who first described the condition.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; ricerca «genetics»).
Fonte: Wikipedia in inglese, voce «XX male syndrome» — https://en.wikipedia.org/wiki/XX_male_syndrome
Wikidata Q365589 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q365589
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/XX_male_syndrome?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1378268707, consultata il 2026-10-07T23:40:15.998Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: d7e84b5d2093be077d3e113d90e6c90b61806af958ca09f0be11df47df63fb15