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Alpha-4 beta-2 nicotinic receptor — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor
License (as archived): CC-BY-SA-4.0
Archived: 2026-11-08T17:08:45.344Z
SHA-256 of the archived text: 95c28e454aeca867d0d40ef1e0bc13e181f2ba12e88b4c00731e7f827013200c
Stable URL of this page: https://metraipolis.com/documento/dc_bd320df2b764

How to cite

Alpha-4 beta-2 nicotinic receptor — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_bd320df2b764 (Metraipolis archive dc_bd320df2b764, sha256 95c28e454aeca867d0d40ef1e0bc13e181f2ba12e88b4c00731e7f827013200c)

BibTeX

@misc{dcbd320df2b764,
  title = {Alpha-4 beta-2 nicotinic receptor — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_bd320df2b764; sha256 95c28e454aeca867d0d40ef1e0bc13e181f2ba12e88b4c00731e7f827013200c},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor implicated in learning, consisting of α4 and β2 subunits. It is located in the brain, where activation yields post- and presynaptic excitation, mainly by increased Na+ and K+ permeability. Stimulation of this receptor subtype is also associated with growth hormone secretion. People with the inactive CHRNA4 mutation Ser248Phe are an average of 10 cm (4 inches) shorter than average and predisposed to obesity. A 2015 review noted that stimulation of the α4β2 nicotinic receptor in the brain is responsible for certain improvements in attentional performance; among the nicotinic receptor subtypes, nicotine has the highest binding affinity at the α4β2 receptor (ki=1 nM), which is also the primary biological target that mediates nicotine's addictive properties. The receptors exist in the two stoichiometries: (α4)2(β2)3 receptors have high sensitivity to nicotine and low Ca2+ permeability (HS receptors) (α4)3(β2)2 receptors have low sensitivity to nicotine and high Ca2+ permeability (LS receptors)

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (deposito sistematico; retro-catalogo: tutte le voci di Wikipedia in inglese, in ordine alfabetico).
Fonte: Wikipedia in inglese, voce «Alpha-4 beta-2 nicotinic receptor» — https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor
Wikidata Q4734895: «type of nicotinic acetylcholine receptor» (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q4734895
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Alpha-4_beta-2_nicotinic_receptor?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1378375376, consultata il 2026-11-08T17:04:56.534Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 46311b1c63627d89cd774e68c7236fe931e60f8a33c1c227eb37c294afaeaab2