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Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive… — Europe PMC PMID:31461445

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31461445
DOI: 10.1371/journal.pone.0220788
License (as archived): CC0-1.0
Archived: 2026-11-10T18:26:51.747Z
SHA-256 of the archived text: adea33bb1664914947a858e7ae0d80eb53d457632c4956b5bb25ee75cc7a5c29
Stable URL of this page: https://metraipolis.com/documento/dc_bd2e2ef44328

How to cite

Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive… — Europe PMC PMID:31461445 — Europe PMC (en), https://europepmc.org/article/MED/31461445 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_bd2e2ef44328 (Metraipolis archive dc_bd2e2ef44328, sha256 adea33bb1664914947a858e7ae0d80eb53d457632c4956b5bb25ee75cc7a5c29)

BibTeX

@misc{dcbd2e2ef44328,
  title = {Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive… — Europe PMC PMID:31461445},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31461445},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_bd2e2ef44328; sha256 adea33bb1664914947a858e7ae0d80eb53d457632c4956b5bb25ee75cc7a5c29},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31461445. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Introduction: Current treatments for overactive bladder (OAB) are often discontinued due to side effects or lack of efficacy. The goal of this study was to determine if combining a phosphodiesterase type 4 inhibitor (PDE4i); with a type 5 inhibitor (PDE5i); would have a beneficial effect on OAB symptoms and if a reduced dose of PDE4i in combination with PDE5i could also provide a beneficial effect in OAB. We hypothesized that PDE5i and PDE4i combination treatment could be utilized to reduce non-voiding contractions and smooth muscle disruption in a rat model of OAB. Methods: Fifty-eight age-matched Sprague-Dawley rats underwent PBOO and daily gavage with PDE4i alone (roflumilast; 1mg/kg), PDE5i alone (tadalafil;10mg/kg), high dose combination (PDE4i 1mg/kg, PDE5i 10mg/kg), low dose combination (PDE4i 0.2mg/kg, PDE5i 10mg/kg), or vehicle for 28 days. Fourteen animals underwent sham PBOO with vehicle. Rats underwent conscious and anesthetized cystometry 28 days after PBOO and were euthanized for qualitative bladder histology. One-way ANOVA on ranks with a Dunn's post hoc test was used to indicate statistically significant differences between groups (p<0.05). Results: Bladder & urethral weight was significantly increased after PBOO with vehicle, PDE4i alone, and PDE5i alone, but not with either combination treatment. Frequency of non-voiding contractions during both conscious and anesthetized cystometry increased significantly after PBOO with vehicle, but not after PDE4i or high dose combination treatments compared to sham PBOO. Threshold pressure for voiding was significantly decreased with high dose combination compared to vehicle. PBOO treated with PDE4i alone or high dose combination showed less bladder smooth muscle fibrosis than vehicle, PDE5i alone, or low dose combination treatments. Conclusion: A PDE4i and PDE5i combination treatment has potential benefit in reducing OAB symptoms, but future research is needed.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-08-28).
Identificativi: PMID 31461445 · PMCID PMC6713339 · DOI 10.1371/journal.pone.0220788.
Pagina: https://europepmc.org/article/MED/31461445 — https://doi.org/10.1371/journal.pone.0220788. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
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